I . Rats were given a rachitogenic diet for 28 days; some were dosed with vitamin D z or 3 days before they were killed and some received vitamin D throughout the experiment. 2. Parathyroid leucine aminopeptidase was measured histochemically as an index of parathyroid activity and silver impregnation as a criterion of bone calcification. 3. Calcium and phosphorus were estimated in bone ash and ...

Sevento eight-day mouse tail vertebrae were transplanted under the renal capsules of syngeneic adult animals and allowed to grow for up to 6 months. Their curve of growth and histological pattern of ageing were similar to those of control vertebrae which had been left in their normal position on young animals. Slices of the growth cartilage of sevento eight-day rat tail vertebrae were similarly...

Primary growth hormone (GH) resistance describes growth failure in the presence of normal, or even elevated, GH secretion. In its classic form, the phenotype is identical to that of GH deficiency, and was originally described in association with defects of the GH receptor. With increasing understanding of the GH-insulin-like growth factor (IGF) axis, it has become apparent that GH resistance ca...

Introduction and objectives NOMID, also known as CINCA syndrome, is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. The pathophysiology of NOMID is explained by gain of function mutation of NLRP3, which activates NLRP3 inflammasome and produce an excess of IL-1b. This mechanism is supported by clinical observation that anti-IL-1 therapy is effective on its systemic in...

dysplasia epiphysealis hemimelica is a rare nonhereditary epiphyseal disease that mimics synovial chondromatosis and osteochondroma of the joints. the disease mainly involves long bones of the lower extremities and tarsal bones. herein we report 21-year old woman who presented with pain and limited range of ankle motion, who underwent surgical excision of talus exostosis after preoperative imag...

Simultaneous ipsilateral distal and proximal fractures of the forearm are rare [1-3]. There have been case reports describing an olecranon fracture associated with an ipsilateral distal radius epiphyseal injury[1], a Monteggia lesion with an associated ipsilateral distal radius epiphyseal injury[4] or associated with ipsilateral distal radius and ulna metaphyseal fractures[5, 6]. Furthermore, t...

Extracellular cathepsin D has been demonstrated immunohistochemically in cultured chicken and rabbit cartilage. Enzyme released from viable cells was captured by specific anti-cathepsin D antibody to form extracellular immunoprecipitates which were demonstrated with fluoresceinlabelled antibodies. In unfixed frozen sections these immunoprecipitates could be dissolved in antigen excess, and clos...

Disruption to endochondral ossification leads to delayed and irregular bone formation and can result in a heterogeneous group of genetic disorders known as the chondrodysplasias. One such disorder, multiple epiphyseal dysplasia (MED), is characterized by mild dwarfism and early-onset osteoarthritis and can result from mutations in the gene encoding matrilin-3 (MATN3). To determine the disease m...