Domestic Mongolian gerbils, a model of inherited epilepsy, begin having spontaneous seizures at ~1.5 months of age, making it possible to evaluate them during epileptic and pre-epileptic stages. Previous studies have shown that GABA-binding is reduced in the substantia nigra pars reticulata (SNr) of both epileptic and pre-epileptic gerbils compared with controls, suggesting that reduced express...

Epileptic seizures can develop from the synchronous and paroxysmal activation of a group of neurons. There is high prevalence of a heterogeneous variety of epileptic syndromes in the population. A great number of people suffer from an epileptic seizure at least once in their lives, are worried, go to the emergency room, and seek for medical advice. It is therefore important for every physician ...

Epileptic seizures can develop from the synchronous and paroxysmal activation of a group of neurons. There is high prevalence of a heterogeneous variety of epileptic syndromes in the population. A great number of people suffer from an epileptic seizure at least once in their lives, are worried, go to the emergency room, and seek for medical advice. It is therefore important for every physician ...

Nonepileptic seizures can be difficult to distinguish from epileptic seizures: they may look exactly like epileptic seizures. The difference is that during a nonepileptic seizure, there are no abnormal electrical discharges in the brain of the type seen in epileptic seizures. Nonepileptic seizures can have many causes; however, the most common cause is a psychiatric illness. In these illnesses ...

Domestic Mongolian gerbils, a model of inherited epilepsy, begin having spontaneous seizures at approximately 1.5 mo of age, making it possible to evaluate them during epileptic and pre-epileptic stages. Previous studies have shown that GABA binding is reduced in the substantia nigra pars reticulata (SNr) of both epileptic and pre-epileptic gerbils compared with controls, suggesting that reduce...

Aims: To assess and compare the body mass index (BMI), serum leptin, and lipid peroxidation represented by serum malondialdehyde (MDA) levels in epileptic patients on valproate (VPA) and topiramate (TPM) monotherapy for at least 6 months taking in consideration dosage and duration of therapy, in comparison to healthy controls. Methods: A cross-sectional, case-series study design was adopted, fo...

OBJECTIVE The poor sleep quality of epileptic patients may be partly due to the occurrence epileptiform discharges (EDs). We observed the number of interictal discharges in each sleep stage and explored the associations between EDs and sleep phases in epileptic patients. METHODS Two hundred epileptic patients and 182 healthy volunteers were enrolled in the current study. For all subjects, vid...