Purpose10-year retrospective study to assess burden of illness in individuals with tuberous sclerosis complex (TSC) identified from German healthcare data.MethodsPatients TSC were by International Classification Diseases code Q85.1. Patients epilepsy diagnosis or antiseizure medication (ASM) prescription after diagnosis.ResultsUsing data 2016 (final year), 100 patients (mean [range] age: 38 [1–...

Objective To characterize the PET-MRI co-registration of hypometabolic patterns in focal cortical dysplasia (FCD) types I and II provide some suggestions presurgical evaluation epilepsy surgery. Methods We retrospectively analyzed imaging data from a cohort 83 patients with histologically confirmed FCD II. Hypometabolic were classified into 4 types: bottom sulcus hypometabolism (BOSH), single i...

background previous studies provided inconsistent associations of smoking, stroke, and serious psychological distress (spd) with epilepsy while urban-rural differences in the associations of risk factors with epilepsy are not well documented. objectives this study aimed to evaluate the associations of lifestyle, health conditions, and spd with epilepsy and to examine whether the associations di...

Patients with drug refractory temporal lobe epilepsy frequently accumulate cognitive impairment over time, suggesting neuronal loss induced by seizures. We measured serum levels of neuronspecific enolase (NSE), a neuronal injury marker, relative to levels of S100β, a marker of glial injury, at 6 AM, 9 AM, noon, 3 PM, and 6 PM over the course of several days in 7 epilepsy patients and 4 healthy ...

Many recent epidemiological studies have found the prevalence of depression and anxiety to be higher in people with epilepsy (PWE) than in people without epilepsy. Furthermore, people with depression or anxiety have been more likely to suffer from epilepsy than those without depression or anxiety. Almost one-third of PWE suffer from depression and anxiety, which is similar to the prevalence of ...

Epilepsy is a condition that affects the brain and causes repeated seizures. Epilepsy is the second most common neurological disorder, affecting 0.6–0.8% of the world’s population. In this neurological disorder, abnormal activity of the brain causes seizures, the nature of which tend to be sudden. The cells in the brain, known as neurons, conduct electrical signals and communicate with each oth...

Epilepsy is the most prevalent neurological disorder in humans after stroke. Recurrent seizure is the main characteristic of the epilepsy. Electroencephalogram (EEG) is the recording of brain electrical activity and it contains valuable information related to the different physiological states of the brain. Thus, EEG is considered an indispensable tool for diagnosing epilepsy in clinic applicat...

PURPOSE Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur in the electro- (EEG) and magnetoencephalogram (MEG) in case of focal epilepsy...

A brain computer interface (BCI) is a communication system converting neural activities into signals that can control computer cursors or external devices (Fetz, 2007). BCI was initially and mainly employed for patients with severe motor disorders such as amyotrophic lateral sclerosis (ALS) by providing non-muscular bidirectional communication and control. How‐ ever, the application of BCI has ...

Focal cortical dysplasia (FCD) is the most common cause of pediatric epilepsy and the third most common lesion in adults with treatment-resistant epilepsy. Advances in MRI have revolutionized the diagnosis of FCD, resulting in higher success rates for resective epilepsy surgery. However, many patients with histologically confirmed FCD have normal presurgical MRI studies ('MRI-negative'), making...