Pemphigus vulgaris is an autoimmune bullous dermatosis presenting with flaccid blisters and erosions. The morphology of pemphigus reflects the more superficial intraepidermal level split seen histologically in contrast pemphigoid, where deep below epidermis. This a case 58-year-old male clinically arcuate tense bullae, which are characteristic pemphigoid group disorders, revealed tombstoning pa...

The normal skin is from 0.5 to 10 millimetres thick, varying from place to place in the body, and consists of two layers, the epidermis and the dermis. The more superficial layer of the skin is the avascular epidermis which consists of stratified epithelium accurately moulded on the papillae of the corium , or true skinThe lowest or the deepest layer of the epidermis is known as the basal layer...

Objective. To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods. HIF-1α gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by in situ hybridization. Results. There was positive staining of HIF-1α gene in all the layers of psoriatic epidermis (100.0%) before the treatment with capsaicin ointment,...

Triglycerides and phospholipids play an important role in epidermal permability barrier formation and function. They are synthesized de novo in the epidermis via the glycerol-3-phosphate pathway, catalyzed sequentially by a group of enzymes that have multiple isoforms including glycerol-3-phosphate acyltransferase (GPAT), 1-acylglycerol-3-phosphate acyltransferase (AGPAT), Lipin and diacylglyce...