Abstract Background Epidermal growth factor receptor (EGFR) mutations in non–small-cell lung cancer predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs). mutation types are associated with efficacy of TKIs. We investigated the clinical outcomes afatinib, erlotinib, and gefitinib according type patients adenocarcinoma. Methods Between May 2010 December 2018, we 363 advanced adenocarcino...

OBJECTIVE Apocrine carcinoma, a subtype of invasive ductal carcinoma of the breast, expresses androgen receptor (AR), but often lacks estrogen receptor (ER) and progesterone receptor (PgR). In the present study, the author immunohistochemically defined apocrine-type carcinoma as ER-/PgR-/AR+ invasive ductal carcinoma and analyzed the significance of apocrine-type carcinoma as triple-negative br...

To clarify association of epidermal growth factor receptor, human receptor 2 with prognosis colorectal cancer under FOLFOX chemotherapy. A total 108 patients chemotherapy in the hospital from October 2017 to 2019 were chosen as research subjects. The baseline data recorded before treatment and levels serum tumor markers carcino embryonic antigen carbohydrate 125 measured recorded. After 6 cours...

Seventeen fresh uncultured tumors obtained from biopsies of patients with various forms of head and neck cancer and two squamous cell carcinoma cell lines were analyzed for RNA expression and structural alterations of the epidermal growth factor reception gene. We used cDNA probes for the external and the internal domains of the gene. Enhanced mRNA expression was found only in one squamous cell...