The foregoing commentaries demonstrate wide differences between their authors’ choice of terms describing epidemiologic research designs, and in the relative importance they attach to directionality, timing, and sample selection. Nowhere is this more evident than in their discrepant definitions of “prospective” and “retrospective” studies. According to Drs Greenland and Morgenstern, “Prospectiv...

Background: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the a questionnaire on medication use by comparison with health insurance claims and identify individual determinants discordance Tsuruoka Metabolomics Cohort Study.

Genetic epidemiology is a young but rapidly developing discipline. Although its early years were largely dedicated to family-based research in monogenic disorders, now genetic-epidemiologic research increasingly focuses on complex, multifactorial disorders. Along with the development of the human-genome map and advances in molecular technology grows the importance of genetic-epidemiologic appli...

This issue of Epidemiologic Reviews on cohort studies is published five decades after the initiation of the Framingham study, one of the landmark investigations of epidemiologic research and, more generally, contemporary biomedical research. Within a few years other cohort studies—for example, of British physicians and of the atomic bomb survivors—were initiated. As follow-up of the participant...

background: data on premature coronary artery disease (cad) are scarce. the tehran heart center's premature coronary atherosclerosis cohort study (thc-pac) is the first study of its kind in the middle east to assess major adverse cardiac events (mace) in young cad patients. methods: the cohort consists of cad patients, males ≤ 45 years old and females ≤ 55 years old. the participants are reside...