Lignocellulosic plant biomass is recognized as an alternative resource for sustainable production of liquid fuels, chemicals, and polymeric materials through the biorefining concept. The sugar platform one promising approaches commercial conversion cellulose and/or hemicelluloses in into targeted products biologically chemically carbohydrate saccharification. However, efficient, from lignocellu...

Up to day, very little work has been done on the antimicrobial activity of spices extracts against food pathogens. Additionally, there is information about antioxidant activities spices. The aim this was investigate effects pathogens, and its non-enzymatic potentials. plants have provided from C2 region Mugla local herbalists. Antimicrobial were evaluated using disc diffusion method. showed max...

The insulin-like growth factor-1 receptor (IGF1R) is a drug target for oncology, and many studies are ongoing to identify compounds that inhibit its tyrosine kinase activity. IGF1R is highly homologous to the insulin receptor (IR) and IGF1R inhibition might be beneficial for patients, while IR inhibition may lead to limiting toxicity. Therefore selectivity for IGF1R over IR is the aim for drug ...

The enzymatic hydrolysis of cellulose and lignocellulosic materials is marked by a rate decrease along the reaction time. Cellobiohydrolase slow dissociation from the substrate and its inhibition by the cellobiose produced are relevant factors associated to the rate decrease. In that sense, addition of β-glucosidases to the enzyme cocktails employed in cellulose enzymatic hydrolysis not only pr...

The enzymatic properties of a new glucose-6-phosphate dehydrogenase (G-6-PD) variant (G-6-PD Long Prairie) were studied in a white patient with chronic nonspherocytic hemolysis. The red cells were found to have 2.3%-7.7% normal enzymatic activity. The mutant enzyme exhibited marked heat instability, an increased pH optimum, a moderately decreased Km for G-6-P, and increased utilization of 2-deo...

An improved model for enzymatic hydrolysis of cellulose is developed that considers oligomer reactions with beta-glucanases, inhibition of oligomers to cellulases and enzyme decay processes during hydrolysis. Our oligomer reactions with beta-glucanases are modeled based on the enzymatic glucan chain fragmentation kinetics to describe the further fragmentation of oligomers in solution after bein...

Non-enzymatic glycation is a complex series of reactions between reducing sugars and amino groups of proteins. Accumulation of AGEs (advanced glycation end-products) due to non-enzymatic glycation has been related to several diseases associated with aging and diabetes. The formation of AGEs is accelerated in hyperglycaemic conditions, which alters the structure and function of long-lived protei...

Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in plasma and is potentially capable of degrading the anchor utilized by many cell surface proteins. The goal of this work was to study structural features of the GPI-PLD that might be involved in regulation of its activity. Trypsin cleaved the 100-110 kDa GPI-PLD polypeptide into three major fragments (two of approxima...

The acid and alkaline phosphatase activities of the clam Scrobicularia plana have been partially characterised in different organs and tissues (digestive gland, gills, foot, siphon and mantle) and the 'in vitro' effect of heavy metals on both types of enzymatic activity have been analysed. The optimal pH ranged between 4.0 and 5.5 for acid phosphatase activity and 8.5 and 9.5 for alkaline phosp...