RNA modifications are omnipresent among non-coding RNAs, so much so that pseudouridine (an isomer of uridine) was originally designated the ‘fifth nucleoside’. Their role ranges from fine-tuning to being functionally essential to their target RNAs. Ever since their discovery some 60 years ago, RNA modifications were considered constitutive. In this issue of The EMBO Journal, however, Wu et al d...

Cellular memory, which allows cells to retain information from their environment, is important for a variety of cellular functions, such as adaptation to external stimuli, cell differentiation, and synaptic plasticity. Although posttranslational modifications have received much attention as a source of cellular memory, the mechanisms directing such alterations have not been fully uncovered. It ...

The United Arab Emirates is witnessing enormous growth and the sustainability attitude has become one of most important priorities in this development. This paper aims to optimize environmental Emirate Dubai communities by adopting an existing community as a case study. investigation study looking at levels that consists two major factors neighborhood sustainable design, such livability thermal...

Human transmission to offspring and future generations of acquired epigenetic modifications has not been definitively established, although there are several environmental exposures with suggestive evidence. This article uses three examples of hazardous substances with greater exposures in vulnerable populations: pesticides, lead, and diesel exhaust. It then considers whether, if there were sci...

This study investigated the seasonal environmental characteristics for tropical cyclone genesis (TCG) over the Indian Ocean during the Cooperative Indian Ocean Experiment on Intraseasonal Variability in the Year 2011 and the Dynamics of the Madden–Julian Oscillation (MJO) (CINDY2011/DYNAMO) field experiment and compare them with long-term climatological features. It was found that the spatial p...

This review highlights current knowledge of environmental factors in carcinogenesis and their cellular targets. The hypothesis that environmental factors influence carcinogenesis is widely supported by both epidemiological and experimental studies. The fact that only a small fraction of cancers can be attributed to germline mutations in cancer-related genes further buttresses the importance of ...

Regulated gene expression by transcription factor networks is critical for normal kidney function. Disruption of these complex networks leads to biochemical aberrations associated with many renal diseases. Epigenetic mechanisms not involving changes in DNA sequence, such as DNA methylation and post-translational modifications of nucleosomal histones, also play a critical role in gene regulation...

Cardiovascular diseases are commonly thought to be complex, non-Mendelian diseases that are influenced by genetic and environmental factors. A growing body of evidence suggests that epigenetic pathways play a key role in vascular biology and might be involved in defining and transducing cardiovascular disease inheritability. In this review, we argue the importance of epigenetics in vascular bio...

isposal of wastewater sludge has D long been a problem in wastewater treatment. In the past decade, however, conventional sludge disposal methods, such as incineration, Ocean dumping and landfilling, have come under increasingly tighi regulatory control. These regulatory cmtrols, coupled with increased energy costs and environmental concerns, have sparked renewed interest in wastewater sludge c...

Animals and humans need to move deftly and flexibly to adapt to environmental demands. Despite a large body of work on the neural control of walking in invertebrates and vertebrates alike, the mechanisms underlying the motor flexibility that is needed to adjust the motor behavior remain largely unknown. Here, we investigated optomotor-induced turning and the neuronal mechanisms underlying the d...