This paper explores the possibilities and core technologies of the ongoing development towards the Semantic Web for desktop application enhancement. It demonstrates how an ontology-based software can provide refined support for personal information organization. The Web Ontology Language and reasoning mechanisms based on Description Logics (DL) are analyzed as enabler technologies for semantic ...

The application of an informative, iterative library design strategy is presented for lead identification and optimization. The computational algorithm underlying informative design systematically uses data from both active and inactive compounds and maximizes the information gained from subsequent design-synthesis-screening cycles. Retrospective analysis of a released dataset of 17 550 compoun...

We present an online learning model of early cross-situational word learning which maps words to objects from context with relatively sparse input. The model operates by rewarding and penalizing probabilities of possible word-to-object mappings based on real-time observation, and using those probabilities to determine a lexicon. We integrate prosodic and gestural cues and allow the learner to e...

Gene expression patterns (motivation) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Transcription factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Experimental discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Computational discovery . . . . . . . . . . . . . . . . . . . . . . . . ...

The present paper describes the individual analytical methodologies (Thermal Ionization Mass Spectrometry, Inductively Coupled Plasma Mass Spectrometry and Alpha Spectrometry) that were developed for uranium age determination and discusses their advantages and drawbacks. With respect to a potential application of the methods (e.g. Fissile Material Cut-off Treaty), the discussion focuses on high...

Measurements of the odd-even effect in the mass spectrometric analysis ofTi and Os isotopes by resonance ionization mass spectrometry have been performed forM = + 1, 0 and -1 transitions. Under saturating conditions of the ionization and forM = + 1 transitions odd-even effects are reduced below the 0.5% level. Depending on the polarization state of the laser large odd isotope enrichments are ob...