Background. Experimental data demonstrate the persistence of a transmural vasodilator reserve in the face of depressed resting myocardial perfusion. The present study was designed to determine whether resting myocardial hypoperfusion indicates exhausted coronary reserve (CR). Methods and Results. Fifteen patients with stable angina, isolated left anterior descending coronary artery (LAD) stenos...

To extend the platform of clinically utilised chemoembolic agents based on ion-exchange systems to support the delivery of anionic drugs, a series of PVA-based beads was produced with different levels of (3-acrylamidopropyl)trimethylammonium chloride (APTA) in their formulation. The beads were characterised to confirm composition and the effect of formulation variation on physical properties wa...

Experiments were performed to determine the effect of hematoporphyrin derivative (HPD) photodynamic therapy on blood flow to normal rat intestine. A segment of rat jejunum was exposed to red (greater than 590 nm) light (200 mW/cm2) 24 h after the i.v. administration of HPD. Blood flow to the light exposed segment was determined using the radioactive microsphere technique while blood flow to an ...

Ambient S annealing was adopted to regulate the crystallinity of a ZnS microsphere, which resulted in a significant improvement in the photocatalytic hydrogen production activity (PHPA). Moreover, with S ambient treatment, wurtzite ZnS showed better PHPA than sphalerite ZnS, possibly because the inter-polar electric field of the wurtzite phase could promote the separation of photo-excited elect...

Over centuries, the field of regenerative skin tissue engineering has had several advancements to facilitate faster wound healing and thereby restoration of skin. Skin tissue regeneration is mainly based on the use of suitable scaffold matrices. There are several scaffold types, such as porous, fibrous, microsphere, hydrogel, composite and acellular, etc., with discrete advantages and disadvant...

OBJECTIVE Endothelium-derived NO has been shown to mediate the mitogenic effect of vascular endothelial growth factor on cultured microvascular endothelium. To evaluate the role of endothelial NO synthase (eNOS) in angiogenesis in the ischemic hindlimb, we engineered an adenovirus containing human eNOS cDNA. METHODS AND RESULTS After gene transfer, expression of eNOS in cultured cells was det...

Design and construction of biocompatible tissue-engineered stents for long segment peripheral nerve regeneration has become a significant research topic. However, in the early of damaged, the immigration and aggregation of inflammatory cells and factors can induce a secondary nerve injury and peroxide damage to the injured nerves, which in turn can result in severe neuronal apoptosis. The use o...

Spherical silica optical microresonators were doped with erbium ions by ion implantation at energies of 925 keV and 2.05 MeV using a rotating stage. After thermal annealing at 800 C, light was coupled into the microsphere using a tapered optical fiber. An optical quality factor as high as 1.9 · 10 was observed at k = 1450 nm, corresponding to a modal loss of only 0.01 dB/cm. When pumped at 1450...

In this Letter, we present a single-exposure deep-UV projection lithography at 254-nm wavelength that produces nanopatterns in a scalable area with a feature size of 80 nm. In this method, a macroscopic lens projects a pixelated optical mask on a monolayer of hexagonally arranged microspheres that reside on the Fourier plane and image the mask's pattern into a photoresist film. Our macroscopic ...

Systematically mapped samples cut from lungs previously labeled with intravascular and aerosol microspheres can be used to create high-resolution maps of regional perfusion and regional ventilation. With multiple radioactive or fluorescent microsphere labels available, this methodology can compare regional flow responses to different interventions without partial volume effects or registration ...