The response to endothelin, a novel 21-amino acid peptide, is investigated in isolated aortas with and without endothelium and in mesenteric microvessels in vivo-in situ, in Goldblatt II (GII) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Median effective concentrations and maximal responses to endothelin did not differ in aortas with endothelium isolated from GII, DOCA-salt hy...

The vasodilatory capacity of insulin has been widely reported, yet some investigators have not noted this effect. Because insulin has been shown to enhance endothelin release, we speculated that endothelin could be attenuating insulin-evoked vasodilation. We examined the effect of ex vivo insulin perfusion on vascular resistance by using the Sprague-Dawley rat mesenteric vascular bed. In methox...

Endothelin-1 (ET-1) is a potent bioactive mediator that induces vasoconstriction and promotes vascular remodeling. Previous studies indicate ET-1 plays an important role in the pathophysiology of humans. This includes various cardiovascular renal complications. Some humans with chronic heart failure might also have failure. The organ damage kidneys increases age. While symptoms will vary accord...

Chronic kidney disease (CKD) is the leading cause of death from non-communicable diseases, and its prevalence in 2017 ranged 8.5 to 9.8%. Depending on stage CKD, 1 was diagnosed 3.5%, 2 3.2% 3 7.6%, while stages 4 5 took place 0.4 0.1% world’s population respectively. Obesity also contributes increase severity their combination occurs 3.1% patients. Kidney damage structural functional changes p...

THE CORONARY CIRCULATION has a remarkable ability to match myocardial oxygen delivery with myocardial metabolism (3, 22). For many years this coupling between coronary blood flow and myocardial oxygen consumption has been proposed to be primarily dependent on production of local metabolites released from cardiomyocytes in proportion to the metabolic rate. Despite decades of intensive research, ...

of Heart Failure To the Editor: We have read with interest the report by Lüscher et al1 on the Heart Failure Endothelin A Receptor Blockade Trial (HEAT). Administration of an endothelin A receptor antagonist, darusentan (30, 100, or 300 mg/d), for 3 weeks significantly decreased systemic vascular resistance with concomitant increase in cardiac index in patients with chronic heart failure (HF). ...

Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study, the expression of endothelin-1 and endothelin receptors was studied in eight human tumour cell lines: T98G (glioblastoma), IMR-32 and NB69 (neuroblastoma), BeWo (choriocarcinoma), SW-13 (adrenocortical carcinoma),...

BACKGROUND Whether ovarian follicular rupture involves contractile activity or not has been debated for decades. Recently, study in the rodents has indicated that an endogenously produced potent vasoconstrictive peptide, endothelin-2 (EDN2), may induce follicular constriction immediately prior to ovulation. This study was aimed to systematically characterize the human ovarian endothelin system ...

We studied the influence of pretreatment with endothelin-1 on cardiac baroreflexes and on the effect of clonidine on blood pressure and heart rate. In order to avoid the complication of the direct vasoconstrictor effects of endothelin-1, initial dose-response studies in animals treated with a ganglion blocker were performed. Intravenous administration of 50, 200, and 1200 ng/kg of endothelin-1 ...

OBJECTIVE To investigate the relation between plasma concentrations of immunoreactive endothelin and haemodynamic variables before and after percutaneous transvenous balloon dilatation of the mitral valve. DESIGN Prospective study. SETTING National cardiovascular centre. PATIENTS 25 patients with mitral stenosis and 26 healthy volunteers. MAIN OUTCOME MEASURES Plasma concentrations of i...