نتایج جستجو برای: endostatin

تعداد نتایج: 1047  

Journal: :Science-Business eXchange 2012

Journal: :Kagaku To Seibutsu 1999

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Mengfeng Li Caisheng Ye Chong Feng Frank Riedel Xiaoning Liu Qing Zeng Jennifer Rubin Grandis

PURPOSE We tested the combined effects of antiangiogenic endostatin and epidermal growth factor receptor (EGFR) antisense gene therapy on squamous cell carcinoma (SCC). EXPERIMENTAL DESIGN AND RESULTS The 1483 cell line of human head and neck SCC (HNSCC) and SCC-VII/SF murine SCC cells was used to establish tumors in nude mice and immunocompetent C3H mice, respectively. Tumor-bearing mice wer...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Darren W Davis Yu Shen Nizar A Mullani Sijin Wen Roy S Herbst Michael O'Reilly James L Abbruzzese David J McConkey

PURPOSE In a recent study, we presented preliminary evidence for biological activity in a Phase I dose-finding study (15-600 mg/m(2)) of recombinant human endostatin in patients with refractory solid tumors. Here, we conducted additional biomarker analyses to correlate changes in tumor biology with dose. EXPERIMENTAL DESIGN Excisional tumor biopsies were obtained at baseline and after 56 days...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
C Mundhenke J P Thomas G Wilding F T Lee F Kelzc R Chappell R Neider L A Sebree A Friedl

PURPOSE The purpose of this study was to determine the effect of the angiogenesis inhibitor endostatin on blood vessels in tumors and wound sites. EXPERIMENTAL DESIGN In a Phase I dose escalation study, cancer patients were treated with daily infusions of human recombinant endostatin. Tumor biopsies were obtained prior to and 8 weeks after initiation of treatment. Blood vessel formation in no...

2006
Zia A. Khan Juan M. Melero-Martin Xiao Wu Sailaja Paruchuri Elisa Boscolo John B. Mulliken Joyce Bischoff

Infantile hemangiomas are composed of endothelial cells (ECs), endothelial progenitor cells (EPCs), as well as perivascular and hematopoietic cells. Our hypothesis is that hemangioma-derived EPCs (HemEPCs) differentiate into the mature ECs that comprise the major compartment of the tumor. To test this, we isolated EPCs (CD133 /Ulex europeus– I ) and mature ECs (CD133 /Ulex europeus– I ) from pr...

Journal: :Investigative ophthalmology & visual science 2001
H C Lin J H Chang S Jain E E Gabison T Kure T Kato N Fukai D T Azar

PURPOSE To localize endostatin and collagen type XVIII in human corneas and to characterize the enzymatic action of matrix metalloproteinases (MMPs) in the cleavage of collagen type XVIII and generation of endostatin in the cornea. METHODS Anti-endostatin and anti-hinge antibodies were generated using peptide fragments corresponding to the endostatin region and the adjacent nonendostatin hing...

2005
He Cheng Li Qiu Yin Cai Eric T. Shinohara Hui Cai Carolyn Cao Zuo Fei Wang Ming Teng Wei Zheng Bo Lu

Endostatin is an important inhibitory molecule which mediates the sequential steps involved in angiogenesis. Lower level or impaired function of endostatin is associated with a higher risk of developing malignant solid tumors and with a worse prognosis of the disease. The endostatin N104 polymorphism might be associated with an impaired ability to inhibit angiogenesis. We analyzed the tissues f...

2010
Shin Young Joo Ji-Eun Kim Ju Young Kim Kyou-Sup Han Hyun Kyung Kim

BACKGROUND Disseminated intravascular coagulation (DIC) is characterized by platelet and neutrophil activation. Platelets are the major source of circulating vascular endothelial growth factor (VEGF). Endostatin, an anti-angiogenic factor, is a fragment of collagen that is released from the extracellular matrix via the active cleavage of neutrophil elastase, thereby increasing the circulating l...

Journal: :Blood 2006
Zia A Khan Juan M Melero-Martin Xiao Wu Sailaja Paruchuri Elisa Boscolo John B Mulliken Joyce Bischoff

Infantile hemangiomas are composed of endothelial cells (ECs), endothelial progenitor cells (EPCs), as well as perivascular and hematopoietic cells. Our hypothesis is that hemangioma-derived EPCs (HemEPCs) differentiate into the mature ECs that comprise the major compartment of the tumor. To test this, we isolated EPCs (CD133(+)/Ulex europeus- I(+)) and mature ECs (CD133(-)/Ulex europeus-I(+)) ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید