scientific evidence regarding the efficacy and safety of the ldm approach in the treatment of psoriasis vulgaris, and positive preliminary data regarding the oral administration of low dose activated cytokines for vitiligo and atopic dermatitis treatment, support the ldm-based therapeutic approach for many dermatological diseases. ldm suggests the use of low-doses of activated biological molecu...

1. Nutrition and Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Dept. of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3. Endo...

Background Endocrine therapy is an effective treatment of estrogen receptor-positive (ER+) breast tumors, significantly reducing mortality. However, approximately 30% of patients receiving adjuvant endocrine therapy will experience recurrence within a 15-year period. The mechanisms of endocrine resistance are poorly understood. Understanding the underlying genetic diversity of breast cancers re...

We examined the spectrum of intermediate cell types in the regenerating pancreas as duct epithelial cells progressed through their differentiation pathway to become mature endocrine cells. The model used was transgenic mice in which the pancreatic islets continue to grow during adulthood, unlike normal mice whose islet cell formation ceases early in life. Because the intermediate cells migrated...

The standard of care for patients with hormone receptor positive, human epidermal growth factor receptor type 2 negative advanced breast cancer is endocrine therapy. Endocrine agents, including aromatase inhibitors, tamoxifen, and fulvestrant, are often administered alone as first line treatment and demonstrate durable responses with limited side effects. Endocrine resistance represents a major...

Endocrine therapy is the primary treatment for most common types of breast cancer. agents work by inhibiting tumor-stimulating effects estrogen in hormone-sensitive tumors. A new class targeted drugs synergize with endocrine to improve survival patients metastatic disease. continued years, and long-term common, although toxicities often occur due alteration physiologic estrogen. It important, t...

Autoimmune polyendocrine syndromes are a heterogeneousgroup of rare diseases characterized by autoimmune activityagainst more than one endocrine organ, although non-endocrineorgans can also be affected. We report the association of APS Iwith erythema annulare centrifugum in an 18-years-old male whopresented with multiple figurate erythema spreading on his trunkand extremities along with a histo...

BACKGROUND Several studies have evaluated the clinical effectiveness of endocrine therapy alone in women aged 70 years or over and who are fit for surgery. OBJECTIVES To identify and review the evidence from randomised trials comparing primary endocrine therapy (endocrine therapy alone) to surgery, with or without adjuvant endocrine therapy, in the management of women aged 70 years or over wi...

Many studies about endocrine pollution in the aquatic environment reveal changes in the reproduction system of biota. We analysed endocrine activities in two rivers in Southern Germany using three approaches: (1) chemical analyses, (2) in vitro bioassays, and (3) in vivo investigations in fish and snails. Chemical analyses were based on gas chromatography coupled with mass spectrometry. For in ...

The European Commission (EC) has missed a unique opportunity to develop a regulatory system that sets new standards in the protection against endocrine-disrupting chemicals. The proposed amendments to the European Union (EU) pesticide law and the criteria for the identification of endocrine disruptors that the EC published on June 15, 2016, after a delay of almost 3 years, ensure that hardly an...