A 10-year-old girl presented with subacute lower limb weakness and gait ataxia. MRI revealed a large multicystic spinal cord lesion with patchy enhancement (figure 1, A and B) and 3 small (,6 mm) periventricular and deep white matter brain lesions. The presence of serum anti-aquaporin-4 (AQP4) immunoglobulin G (ELISA assay) and compatible neuropathologic features from neurosurgical specimens (f...

The effect of cholinergic basal forebrain lesions on immunoreactivity to somatostatin (SOM-i) and neuropeptide-Y (NPY-i) was investigated in the rat parietal cortex, 16-18 months after multiple bilateral ibotenic acid injections in the nucleus basalis complex. As a result of the lesion, the cholinergic fiber density in the cortex decreased by 66% with a concurrent increase in SOM-i fibers by mo...

To be classified as cerebral palsy (CP), there must be difficulty in neuromotor control, a nonprogressive brain lesion, and an injury to the brain that occurred before it was fully mature. The term ‘ ‘cerebral palsy” should be used only if a static encephalopathy exists. If there is any question that a progressive central nervous system disorder exists, the term “cerebral palsy” should not be u...

In 1897 de Quervain, who was then assistant to Kocher, first described the lesion at the wrist joint which now bears his name : “ It appeared that the complaints were due to localised thickening of the tendon sheaths formed by the fibres of the dorsal carpal ligament and that the functional disorder was caused by increased friction at that point.” It is extraordinary that half a century later w...

INTRODUCTION Atherosclerosis is a common arterial disorder, and is of particular clinical significance when it occurs in the coronary arteries since it can result in ischemic heart disease and/or myocardial infarction. The development of atherosclerotic lesions is linked to systemic risk factors including hypertension, hypercholesterolemia, heredity, and smoking [1] as well as local biomechanic...

The case of an HIV-infected man from Eritrea previously diagnosed with tuberculosis, who presented neurological impairment and cerebral lesion after having voluntarily stopped anti-tubercular and antiretroviral therapies, is here reported. Treatments associated with steroids and mannitol were administered. The patient's condition improved, but neuroimaging showed a continuous worsening of the l...

Oculocerebrorenal syndrome is an X-linked recessive disorder characterized by congenital ocular abnormalities, mental retardation, renal disease, and metabolic bone disease. We report a case of oculocerebrorenal syndrome and, using T1-, proton density-, and T2-weighted imaging sequences, are able to characterize two distinct white matter abnormalities: one lesion is punctate and has signal char...

Castleman’s disease is a rare lympho proliferative disorder with unclear pathogenesis. It is found in two forms, localized (uni-centric) and multi-centric. Histologically there are two forms; hyaline vascular and plasma cell type. The disease is definitely diagnosed by histological examination after biopsy. Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Gallium 67 scintigraphy can ...

A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorder, such as the involvement of subcutis, its occurrence in the scalp, and a doc...

Radionuclide imaging is a non-invasive modality based on tracer physiology widely utilized in the diagnosis, staging, therapeutic evaluation, and monitoring of metastatic disease spectrum malignancies. Calcific tendinopathy well-recognized disorder related to deposition calcium hydroxyapatite crystals within tendons. We describe patient with urothelial carcinoma bladder revealing increased upta...