نتایج جستجو برای: end resection
تعداد نتایج: 471996 فیلتر نتایج به سال:
Background and Aims: Considering advantages and disadvantages of mineral trioxide aggregate (MTA), Calcium Enriched Mixture (CEM) cement has been developed recently. The purpose of this study was to compare the apical microleakage of the root-end cavities prepared by ultrasonic or Er,Cr:YSGG laser and filled with MTA or CEM cement. Materials and Methods: Eighty single-rooted, extracted human t...
Cytoreductive surgery is well established in patients with primary ovarian cancer. The benefit of surgery in patients with recurrent ovarian cancer remains a controversial matter. There is a large heterogeneity in surgical results published in the literature, possibly caused by infrastructure, surgeons' philosophy and belief in adding various surgical skills. This might also be a result of diff...
PURPOSE To describe our experience in the diagnosis and treatment of 23 patients with ureteral endometriosis. MATERIALS AND METHODS We performed a retrospective analysis of 23 cases of ureteral endometriosis with histopathological results from 2002 to 2011. RESULTS In patients with ureteral endometriosis, 23 cases were diagnosed by ultrasound, 21 by intravenous urography, 11 by retrograde u...
The distal end of the ulna is an uncommon site for primary bone tumours. We report the case of a 23-year-old male, with a giant-cell tumour of the distal end of the ulna treated with en-bloc resection and stabilisation of the ulnar stump using one half of the extensor carpi ulnaris tendon. The amount of bone removed from the distal end of the ulna was 9.0 centimeters long. The functional and on...
The resection of DNA double-strand breaks (DSBs) into 3' single-strand tails is the initiating step of homology-dependent repair pathways. A key player in this process is the MRE11-RAD50-NBS1 complex, but its contribution to and mechanistic role in resection are not well understood. In this study, we took advantage of the Xenopus egg extract system to address these questions. We found that depl...
DNA double strand breaks (DSBs) can be repaired by either recombination-based or direct ligation-based mechanisms. Pathway choice is made at the level of DNA end resection, a nucleolytic processing step, which primes DSBs for repair by recombination. Resection is thus under cell cycle control, but additionally regulated by chromatin and nucleosome remodellers. Here, we show that both layers of ...
MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic. Here, we employed structure-based design with a focused chemical library to discover specific MRE11 endo- or exonuclease inh...
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