We present histological, MRI, and clinical features of an adult patient with relapsing encephalomyelitis and antibodies against myelin oligodendrocyte glycoprotein (MOG). Furthermore, we report molecular details of the recognized epitope that is specific for human MOG. A brain biopsy revealed multiple sclerosis (MS)-type II pathology. Some features overlapped with both MS and neuromyelitis opti...

Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disorder with an acute or subacute onset, typically of a monophasic nature, which affects multifocal areas of the central nervous system. ADEM is commonly associated with an antecedent or concomitant infection that is usually viral. However, in the last few years, several published reports have indicated an association...

Accepted modes of therapy in acute disseminated encephalomyelitis include intravenous methyl prednisolone, intravenous immunoglobulin or a combination of both. Effectiveness of plasmapheresis has been demonstrated by previous case reports. We report two patients with steroid non-responsive acute disseminated encephalomyelitis in which plasmapheresis resulted in complete clinical and radiologica...

A 16 year boy was admitted with fever, headache, muscle pain, maculopapular rash and progressive altered sensorium. His serum dengue IgM was positive and was improving on conservative management. The patient developed right hemi paresis after 19 days and his MRI revealed multiple white mater lesions. He was diagnosed as acute disseminated encephalomyelitis (ADEM) following dengue hemorrhagic fe...

A non-invasive view of the brain with the aid of magnetic resonance imaging (MRI) is invaluable for studying pathological processes during autoimmune encephalomyelitis. Several MRI technologies are available that can be employed to study inflammation within the brain. These include labeling of inflammatory cells with paramagnetic contrast agents (such as USPIO/SPIO/VSOP iron-oxide or perfluoro ...

The effect of X-irradiation on experimental vaccinia infection of BALB/c mice was studied. As compared with nonirradiated controls, the X-irradiated animals exhibited (i) a time lag in virus replication (delayed, but protracted replication); (ii) a delayed and repressed immune response: (iii) more severe acute cytocidal infection of leptomeninges, choroid plexus, ependyma, and vessels, with ext...

S of these analytical methods using chemicals taken from Eastman Organic Chemical List No. 926 of nearly 3,000 different compounds will be gladly forwarded upon request.

Investigators from Washington University School of Medicine and University of Florida College of Medicine, report that susceptibility-weight imaging (SWI) may be useful in differentiating initial presentation of pediatric multiple sclerosis (MS) from acute disseminated encephalomyelitis (ADEM).

Helmar Waiczies, Stefano Lepore, Jason M Millward, Bettina Purfürst, Thoralf Niendorf, and Sonia Waiczies Ultrahigh Field Imaging in Neuroinflammation, Experimental and Clinical Research Center (ECRC), a cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Deutschland, Germany, Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Center for...