The catalytic activity of racemic thiourea derivatives of Tröger’s base (±)-2–4 in Michael additions of malonate derivatives to trans-β-nitrostyrene was studied. Due to the low basicity of Tröger’s base, the outcome of the addition reactions was strongly dependent on the pKa of the nucleophile. Thiourea catalysts (±)-2, 3 were resolved on the chiral stationary phase Whelk O1. Unfortunately, ena...

A chiral ionic liquid (IL), S-[3-(chloro-2-hydroxypropyl)trimethylammonium] [bis((trifluoromethyl)sulfonyl)amide] (S-[CHTA](+)[Tf(2)N](-)), which can be easily and readily synthesized in a one-step process from commercially available reagents, can be successfully used both as co-electrolyte and as a chiral selector for CE. A variety of pharmaceutical products including atenolol, propranolol, wa...

Este artigo trata da separação enantiomérica do ácido α-cicloexilmandélico contendo cobre(II) N-dodecil-(L)-hidroxiprolina (CuN 2 ) como um carregador quiral, usando uma membrana líquida suportada em fibra oca. Um modelo matemático de transporte e separação enantiomérica de compostos quirais foi deduzido; o coeficiente de partição observado entre a fase de alimentação e a membrana, a fase de el...

Two chiral compounds, Tröger's base and tetrahydropalmatine, were enantioseparated on the (5S, 11S)-(-)-Tröger's base and l-tetrahydropalmatine imprinted monolithic capillary columns with CEC, respectively. The monoliths were prepared by in situ thermal-initiated copolymerization of methacrylic acid (MAA) and ethylene dimethacrylate (EDMA). After optimizing the ratio of porogens (toluene and do...

Chiral separations of 1-aminoindan (AI) by cyclodextrin electrokinetic chromatography (CDEKC) were investigated on microfluidic quartz chips. By using a microchip electrophoresis (MCE) instrument equipped with a linear-imaging UV detector, the separation process of the enantiomeric compounds was observed. When sulfated beta-cyclodextrin was employed as a chiral selector, the baseline separation...

A novel beta-cyclodextrin (beta-CD) derivative modified with a degradable and biocompatible oligo(lactic acid) (OLA) group, 6-oligo(lactic acid)cyclomaltoheptaose (6-OLA-beta-CD), was successfully synthesized and used as a chiral selector for the capillary electrophoretic (CE) resolution (R(s)) of several basic analytes. The primary purpose of the research was to explore the capability of the 6...

The molecular imprinting technique was first introduced into the microchannel of a microfluidic device to form in situ the imprinted polymer for fast enantioseparation of chiral compounds. The molecularly imprinted polymer (MIP) was in situ chemically polymerized on the microchannel wall using acrylamide as the functional monomer and ethylene glycol dimethacrylate as the cross-linker, and chara...

A multi-template imprinted microchannel was prepared by a one-pot in situ imprinting process. The imprinted microchannel led to a novel chip-based strategy for simultaneous multiple enantioseparation. The one-pot imprinting process formed a multi-template imprinted porous thin layer (about 2 μm) on the inner wall of the capillary, which was characterized by scanning electron microscopy, infrare...