نتایج جستجو برای: enantiomers
تعداد نتایج: 3396 فیلتر نتایج به سال:
In this paper, we describe the direct semipreparative resolution of racemic (rac)-propranolol hydrochloride by high-performance liquid chromatography using cellulose tris(3,5-dimethylphenylcarbamate) as chiral stationary phase and mobile phase systems containing petroleum ether and 2-propanol with the use of basic additives. At analytical scale, the retention factor of both enantiomers is less ...
Propranolol is a nonselective beta-adrenergic blocker used as a racemic mixture in the treatment of hypertension, cardiac arrhythmias, and angina pectoris. For study of the stereoselective glucuronidation of this drug, the two propranolol glucuronide diastereomers were biosynthesized, purified, and characterized. A screen of 15 recombinant human UDP-glucuronosyltransferases (UGTs) indicated tha...
This article reports on a novel biocatalytic method for the synthesis of both enantiomers lisofylline based Trametes versicolor laccase, TEMPO as redox mediator and stereocomplementary recombinant alcohol dehydrogenases biocatalysts.
Abstract We study the excitation of asymmetric-top (including chiral) molecules by two-color femtosecond laser pulses. In cases non-chiral excited an orthogonally polarized pulse, we demonstrate, classically and quantum mechanically, three-dimensional orientation. For chiral molecules, show that orientation induced a cross-polarized pulse is enantioselective along propagation direction, namely,...
Abstract Enantiomers are chiral isomers in which the isomer's structure itself and its mirror image cannot be superimposed on each other. Enantiomer selective sensing is critical as enantiomers exhibit distinct functionalities to their image. Discriminating between by optical methods has been widely used these techniques provide nondestructive characterization, however, they constrained intrins...
The objective of this study was to compare the blood-brain barrier (BBB) transport and brain distribution of levo- (R-CZE) and dextrocetirizine (S-CZE). Microdialysis probes, calibrated using retrodialysis by drug, were placed into the frontal cortex and right jugular vein of eight guinea pigs. Racemic CZE (2.7 mg/kg) was administered as a 60-min i.v. infusion. Unbound and total concentrations ...
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