The kinetics of enzymatic desymmetrisation were analysed for the most common kinetic mechanisms: ternary complex ordered (prochiral ketone reduction); ping-pong second (ketone amination, diol esterification, in half reaction); first (diol ester hydrolysis) and both diacids). For plausible values enzyme parameters, product enantiomeric excess (ee) can decline substantially as reaction proceeds t...

The identification of novel pan-sigma receptor (SR) modulators, potentially useful in cancer treatment, represents a new goal of our research. Here, we report on the preparation of novel chiral compounds characterized by a 3-C alkyl chain bridging an aromatic portion to a 4-benzyl-piperidine moiety. All of the studied compounds have been prepared both in racemic and enantiomerically-pure form, ...

A series of chiral complexes the form Ir(NHC)2(aa)(H)(X) (NHC = N-heterocyclic carbene, aa chelated amino acid, X halide) was synthesized by oxidative addition α-amino acids to iridium(I) bis-NHC compounds and screened for asymmetric transfer hydrogenation ketones. Following optimization reaction conditions, NHC, acid ligands, high enantioselectivity achieved when employing Ir(IMe)2(l-Pro)(H)(I...

A new optomechanical chiral resolution scheme for molecules possessing a permanent dipole moment is proposed. The approach involves the following molecular manipulation sequence: (i) alignment electromagnetic pulse, (ii) time-delayed orienting static electric field, and (iii) scattering from frictional surface. method offers various control parameters including pulse duration intensity, field s...

Many alkaloids containing a tetrahydro-β-carboline skeleton have well-known therapeutic effects, leading to increased interest in the synthesis of these natural products. Enantiomers of N-Boc-protected 1-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline [(±)-7], 1-hydroxymethyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline [(±)-8], and 1-hydroxymethyl-6-fluoro-1,2,3,4-tetrahydro-β-carboline [(±)-9] were ...

A comprehensive kinetic analysis of three prototypical autocatalytic cycle models based on the absolute asymmetric Soai reaction is presented. The three models, which can give rise to amplification of enantiomeric excess and mirror-image symmetry breaking, vary by their monomeric, dimeric or trimeric order of the assumed catalytic species. Our numerical approach considered the entire chiral com...