Miniemulsification and emulsion/solvent evaporation techniques were combined to produce poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Those nanoparticles were prepared with different PHBV molar masses and PHBV concentrations to verify their effect on the final particle size. Nanoparticles with an average diameter of 133 nm were obtained when a low molar mass (Mw = 44,350 g/...

This study illustrates the directed self-assembly of mesoporous TiO2 with magnetic properties due to its colloidal crystal structure with Fe3O4. The Fe3O4 nanoparticles were synthesized using co-precipitation techniques to a size of 28.2 nm and a magnetic saturation of 66.9 emu g(-1). Meanwhile, mesoporous titania nanoparticles (MTNs) with a particle diameter of 373 nm, a specific surface area ...

Post-coating of biodegradable polylactides (PLA)/polyethylene glycol (PEG) microspheres with a gelatin film produced by dipping the microspheres into a gelatin solution to reduce the initial drug release burst was investigated. Biodegradable block PLA/PEG microspheres, prepared by w/o emulsion/solvent evaporation, showed that the hydrophilic segment PEG protruded to the sphere surface. However,...

Atorvastatin, an HMG CoA reductase inhibitor, is widely used for the treatment of dyslipidemia and prevention of cardiovascular disease. It belongs to Class 2 of the Biopharmaceutics Classification System owing to its low solubility and high permeability. In vitro dissolution testing is an essential tool for the design of a dosage form. Appropriate selection of dissolution test conditions is es...

felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to bcs class ii category. hence, its low water solubility limits the pharmacological effect. the aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...

Microparticles of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(ε-caprolactone) (PCL) containing resveratrol were successfully prepared by simple emulsion/solvent evaporation. All formulations showed suitable encapsulation efficiency values higher than 80%. PHBV microparticles revealed spherical shape with rough surface and presence of pores. PCL microparticles were spherically s...

We report the holographic photopatterning of a microemulsion with a formamide polar phase and an acrylate monomer-containing nonpolar phase to produce polymer structures with periodic nanoscale porosity. Formamide is a highly polar solvent that forms well dispersed, nonaqueous emulsion droplets within the monomer-containing nonpolar phase before holographic patterning. Photochemically initiated...

This paper describes the conditions of preparation of poly(o-caprolactone) (PCL) microparticles with a mean size between 5 and 10 mm, obtained by a double emulsion-solvent evaporation technique, suitable for oral vaccine delivery. Bovine serum albumin (BSA) was used as water-soluble model antigen for encapsulation. Different parameters influencing the microparticle size, the BSA loading and ent...

ber af problems fer nnr instantaneously While solvent-assisted emulsion systems have met with a degree of success in formulating pressure sensitive adhesives, they have several disadvantages. The solvent content of these systems precludes totally solvent-free adhesives. Also. there is reported evidence that surfactants used to stabilize the emulsion can adversely affect tack properties of the f...