Brain drain in the medical sector is not a new phenomenon, Romania facing this issue since the fall of the communism. Before the integration in the European Union, the warning of an acceleration of the phenomenon was raised, but, until today, no measures were adopted in order to diminish the exodus. Between 2007 and 2010, 8131 medical doctors leaved the country. With some of the poorest health ...

The neural crest is a population of migratory cells that follows specific pathways during development, eventually differentiating to form parts of the face, heart, and peripheral nervous system, the latter of which includes contributions from placodal cells derived from the ectoderm. Stationary, premigratory neural crest cells acquire the capacity to migrate by undergoing an epithelial-to-mesen...

We hypothesized that tumor necrosis factor (TNF)-alpha signaling is essential to inflammation and host defense during Escherichia coli pneumonia. We tested this hypothesis by instilling E. coli into the lungs of wild-type (WT) mice and gene-targeted mice that lack both p55 and p75 receptors for TNF-alpha. The emigration of neutrophils 6 h after instillation of E. coli was not decreased, but rat...

Brainy Africans to Fortress Europe: For Money or Colonial Vestiges? Economic reasons along with cultural affinities and the existence of networks have been the main determinants explaining migration flows between home and host countries. This paper reconsiders these approaches combined with the gravity model and empirically tests the hypothesis that ex-colonial links can still play an important...

Systemic hypoxia produces an inflammatory response characterized by increases in reactive O(2) species (ROS), venular leukocyte-endothelial adherence and emigration, and vascular permeability. Inflammation is typically initiated by mediators released from activated perivascular cells that generate the chemotactic gradient responsible for extravascular leukocyte accumulation. These experiments w...

This study was undertaken to investigate the requirement of β2-integrins (CD11/CD18) for extravasation of neutrophils in mice. After intraperitoneal thioglycollate injection, an in vivo model of inflammation, leukocyte extravasation into the peritoneal cavity was studied in CD18-deficient and wild-type control mice. Before the induction of peritonitis, total and differential leukocyte counts in...

This reflective article sketches the specificity of migratory flows in sub-Saharan Africa, which is essentially intra-regional. While changing dynamically, the distinctive features include increasing female migration, diversification of migration destinations, transformation of labour flows into commercial migration, and emigration of skilled health and other professionals. These migrations tak...

Chronic inflammatory diseases such as atherosclerosis are characterized by an accumulation of macrophages. To design therapies that would reduce macrophage burden during disease, understanding the cellular and molecular mechanisms that regulate macrophage removal from sites of resolving inflammation is critical. Although past studies have considered the local death of macrophages or the possibi...

Previous research has argued that migration forms an essential component to economic convergence between countries, particularly through the labour market. This paper contributes to the debate on the use of the skill cell approach of migration devised by Borjas (2003) by applying it to Honduras in the years following Hurricane Mitch, from 2001 to 2007. Relying on individual cross-sectional data...

RATIONALE Acute lung injury (ALI) is an important cause of morbidity and mortality, with no currently effective pharmacological therapies. Neutrophils have been specifically implicated in the pathogenesis of ALI, and there has been significant research into the mechanisms of early neutrophil recruitment, but those controlling the later phases of neutrophil emigration that characterize disease a...