We isolated and characterized embryonic lethal mutations in piragua (prg). The prg locus encodes a protein with an amino terminus Zinc Finger-Associated-Domain (ZAD) and nine C2H2 zinc fingers (ZF). prg mRNA and protein expression during embryogenesis is dynamic with widespread maternal contribution, and subsequent expression in epithelial precursors. About a quarter of prg mutant embryos do no...

The stability of citrate-capped silver nanoparticles (AgNPs) and the embryonic developmental toxicity were evaluated in the fish test water. Serious aggregation of AgNPs was observed in undiluted fish water (DM-100) in which high concentration of ionic salts exist. However, AgNPs were found to be stable for 7 days in DM-10, prepared by diluting the original fish water (DM-100) with deionized wa...

With the advent of transgenic pigs using the somatic cell nuclear transfer (SCNT), SCNT pig was thought to hold great promise in basic research, as well as in agricultural and biomedical applications, including xenotransplantation [1,2]. However, SCNT in pigs is limited by substantial problems with the current technologies, including extremely low efficiency, early embryonic and fetal mortality...

Natural populations carry deleterious recessive alleles which cause inbreeding depression. We compared mortality and growth of inbred and outbred zebrafish, Danio rerio, between 6 and 48 days of age. Grandparents of the studied fish were caught in the wild. Inbred fish were generated by brother-sister mating. Mortality was 9% in outbred fish, and 42% in inbred fish, which implies at least 3.6 l...

A novel 66-kDa protein, named p66mot-1, is identified to be associated with cellular mortality by virtue of its presence in cytosolic fractions of serially passaged mouse embryonic fibroblasts (MEF) and the mortal hybrids obtained by the fusion of mortal (MEF) and immortal (MN48-1, derivative of NIH 3T3) cells. Immortal cells lack this protein in their cytosolic fractions. cDNA cloning and homo...

background: perinatal mortality rate is an important indicator of community health status. this study aimed to evaluate perinatal mortality and its determinants in mobini hospital of sabzevar, iran. methods: this descriptive, cross-sectional study was performed within a two-year (2011-2012) period at mobini hospital of sabzevar. our study population included all the cases of stillbirth and live...

Objective(s) In this study we investigated the expression of GABAA receptor subunits during brain development. These receptors may change in the embryonic chick forebrain. Materials and Methodes The expression levels of four types of GABAA receptor gamma subunits (γ1, γ2, γ3 and γ4) were quantified in the embryonic chick forebrain at 32 hr, 3, 7, 14, and 20 days of incubation and day one aft...

The increase in human population had to the demand for vital resources, including food, generating intensive and extractive exploitation, impacting natural ecosystems biodiversity. Land degradation of is a serious widespread problem world. expansion agricultural frontier by direct or indirect human-induced processes, expressed as long-term reduction loss industrialization agriculture been negat...