STUDY QUESTION Is DNA methyltransferase 1 (DNMT1) dysfunction involved in epigenetic deregulation of placentae from embryos obtained by assisted reproduction technologies (ARTs)? SUMMARY ANSWER DNMT1 expression in growing placentae of in vitro produced (IVP) embryos is compromised and associated with pregnancy loss. WHAT IS KNOWN ALREADY DNMT1 maintains the methylation profile of genes duri...

Background Auto-immunization was proposed as the mechanism of contralateral testicular damage following unilateral vas deferens injuries. The objective of this experimental in vitro study was to elucidate the effect of tacrolimus (TS) as a powerful immunosuppressant on contralateral epididymal sperm fertilizing capacity following unilateral vas deferens obstruction (UVO) in mice. MaterialsAndMe...

support of the individual rights and freedom is one of the purposes of criminal procedural rules. police detention or surveillance is contrary to the individual rights. in accordance with obvious rules, police at both american and iranian systems of justice might arrest someone. this matter has an exceptional aspect. it is essential to observe two provisions in which include “visible crime” and...

the society for assisted reproductive technology (sart) method of embryo grading is unique, simple, and widely practiced, and its use has been mandatory for sart membership programs since 2010. developed by sart in 2006, the current embryo grading system categories, “good, fair, and poor,” are limited because they do not describe the best 1-2 embryos in the interest of keeping pace with the shi...

Introduction: Cardiovascular disease is considered as the most important cause of mortality among men and women throughout the world. This condition causes sudden cardiac arrest in more than half of the cases. To reduce mortality due to this disease, cardiopulmonary resuscitation (CPR) and the determinants of its success are the focus of researchers. Objective: The aim of this study was to det...

objective: the objective of this study was to investigate the pathological alterations of methionine for chicken embryo.in recent years, amino acids are used in veterinary medicine for many purposes. they injected into hatching eggs to increase chick body weight and performance at hatch, but the adverse effects of amino acids have always been a major concern. there is scant information availabl...

The Society for Assisted Reproductive Technology (SART) method of embryo grading is unique, simple, and widely practiced, and its use has been mandatory for SART membership programs since 2010. Developed by SART in 2006, the current embryo grading system categories, “good, fair, and poor,” are limited because they do not describe the best 1-2 embryos in the interest of keeping pace with the shi...

Calcium ions generate ubiquitous cellular signals. Calcium signals play an important role in development. The most obvious example is fertilization, where calcium signals and calcium waves are triggered by the sperm and are responsible for activating the egg from dormancy and cell cycle arrest. Calcium signals also appear to contribute to cell cycle progression during the rapid cell cycles of e...

Arrested embryonic development involves the downregulation or cessation of active cell division and metabolic activity, and the capability of an animal to arrest embryonic development results in temporal plasticity of the duration of embryonic period. Arrested embryonic development is an important reproductive strategy for egg-laying animals that provide no parental care after oviposition. In t...