Human African Trypanosomiasis (HAT), also known as Sleeping Sickness, has been one of the most important human diseases in Africa because of widespread epidemics in the past, its very high level of mortality, and its negative influence on the development of rural populations. Two forms of the disease exist, one chronic form in West and Central Africa caused by Trypanosoma brucei gambiense (.95%...

We believe that NGOs, engaged in leprosy control in metropolitan cities where there are many dermatologists in medical colleges, or in private practice, have a special responsibility in implementing leprosy work in an integrated manner. It may be worthwhile narrating the experience of over 3 decades of the Bombay Leprosy Project (BLP) as the Project has been constantly striving to practise all ...

the sources of groundwater pollution such as, industrial effluents, sewage and extensive farming have lead to agrochemical pollution. mathematical modeling helps to analyze the existing situation, allows forecasting, and to evaluate the effects of changes in the surrounding water quality. the present research has been focused mainly towards understanding the various processes affecting the tran...

normal 0 false false false en-us x-none fa background: electroencephalography (eeg) has vital and significant applications in different medical fields and is used for the primary evaluation of neurological disorders. hence, having easy access to suitable and useful signal is very important. artifacts are undesirable confusions which are generally originated from inevitable human activities such...

one of the most paramount processes that play a considerable role in reducing the concentration of heavy metals during estuarine mixing is flocculation. not only does such a process cause a huge percentage of metals to come into the particulate phase, but also it provides ample nutrients for the aquatic life. in the present study, impact of such factors as salinity, ph and do on flocculation of...

BACKGROUND There are growing demands for predicting the prospects of achieving the global elimination of neglected tropical diseases as a result of the institution of large-scale nation-wide intervention programs by the WHO-set target year of 2020. Such predictions will be uncertain due to the impacts that spatial heterogeneity and scaling effects will have on parasite transmission processes, w...

Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target e...

Antibiotic self-resistance mechanisms, which include drug elimination, drug modification, target modification, and drug sequestration, contribute substantially to the growing problem of antibiotic resistance among pathogenic bacteria. Enediynes are among the most potent naturally occurring antibiotics, yet the mechanism of resistance to these toxins has remained a mystery. We characterize an en...