In attempts to derive pharmacokinetic constants from effect data three methods were explored, using non-depolarizing neuromuscular blocking drugs as the paradigm for obtaining effect data. The first method, based on the simple assumption that following two doses, the drug concentrations at times of equal effect during recovery, were equal. Provided that recovery took place in the log-linear dru...

Singlet and triplet potential energy surfaces for the reactions of oxygen atoms ((3)P and (1)D) with CF(3)CN have been studied computationally to evaluate the reaction mechanisms, possible products, and rate constants. On the triplet surface, six kinds of pathway are revealed, namely: direct fluorine abstraction, C-addition/elimination, N-addition/elimination, substitution, insertion and F-migr...

The disposition of 5-fluorouracil (FUra) was studied in 19 colorectal cancer patients dunrng treatment with FUra and high-dose leucovorin (LV) with or without interferon x2a (IFN-a). All received LV 200 mg mIover 2 h. then FUra 400 mg m-2 over 5 min then FUra 400 mgm ' over 22 h. repeated on day 2. on a 14 day cycle. Nine patients also received IFN-a 6 MU every 48 h, starting at least 2 weeks b...

behavioral problems in cats have drawn more attention in recent years since they affect the cat-owner relationship. this study was designed to study the rate of cats with undesirable behaviors according to their owners. frequency of behavioral problems in 167 cats attending small animal hospital, faculty of veterinary medicine, university of tehran, was evaluated using a questionnaire. accordin...

In the context of mod-Gaussian convergence, as defined previously in our work with J. Jacod, we obtain asymptotic formulas and lower bounds for local probabilities for a sequence of random vectors which are approximately Gaussian in this sense, with increasing covariance matrix. This is motivated by the conjecture concerning the density of the set of values of the Riemann zeta function on the c...

Some positivity conjectures are made generalizing known results for Gaussian posets. For a sequence of non-negative integers ~ a = (a 1 ; a 2 ; ; a n), and a non-negative integer m, MacMahon 1, p. 137] considered the rational function of q,

V r /2 t,p/2 is a scaled version of Gaussian measure with r p if 1 < p < 2 and r p ′ if 2 < p < ∞ with 1/p 1/p′ 1. Conversely if F is a holomorphic function which is in a “slightly” smaller space, namely L C, V r/2 t,p/2 , then it is shown that there is a function f ∈ L R, ρ such that e−tHf F. However, a single necessary and sufficient condition is obtained for the image of L2 R, ρp/2 under e−t...

Rate constants for uptake and elimination of chemicals in organisms are often related to partition coefficients (typically the octanol-water partition coefficient). We show that the well-mixed one-compartment model for toxico-kinetics implies that the elimination rate is inversely proportional to the square root of the partition coefficient. When chemical exchange is limited by diffusion in the...