The ability of listeners to detect level differences between two sinusoidal stimuli in a two-interval forced-choice procedure was measured as a function of duration and level in three conditions: (1) the pedestal was fixed in level and the stimuli in the two intervals had the same frequency of either 1 or 2 kHz (fixed-level condition); (2) the pedestal was roved in level over a 20-dB range from...

Computational models of spatial vision typically make use of a (rectified) linear filter, a nonlinearity and dominant late noise to account for human contrast discrimination data. Linear-nonlinear cascade models predict an improvement in observers' contrast detection performance when low, subthreshold levels of external noise are added (i.e., stochastic resonance). Here, we address the issue wh...

Mechanisms determining the structure of edge temperature and density pedestals, which are associated with edge transport barrier (ETB) formation in tokamaks, are investigated on Alcator C-Mod. Experiments suggest a strong role for critical gradient behavior in setting profile characteristics of edge plasma. The maximum pressure gradient scales as the square of plasma current in both H-modes wit...

Some studies have reported deficits in amblyopia for global form and motion integration, whereas other studies have shown global integration of form and motion information to be normal in amblyopia. Here, we attempt to resolve this discrepancy by showing that amblyopes only exhibit selective performance deficits on global tasks that contain noise as well as signal. We hypothesized that signal i...

The stressful quality of an experience, as perceived by rats, is believed to be largely represented by the magnitude of a hypothalamic-pituitary-adrenal (HPA) axis response. The hippocampus may be especially important for assessing the stressfulness of psychological stressors such as novel experience. If such is the case then experience-dependent immediate-early gene expression levels within th...

Although cortical activation to binocular disparity can be demonstrated throughout occipital and parietal cortices, the relative contributions to depth perception made by different human cortical areas have not been established. To investigate whether different regions are optimized for specific disparity ranges, we have measured the responses of occipital and parietal areas to different magnit...

Bacterial pathogens sense host cues to activate expression of virulence genes. Most of these signals are sensed through histidine kinases (HKs), which comprise the main sensory mechanism in bacteria. The host stress hormones epinephrine (Epi) and norepinephrine are sensed through the QseC HK, which initiates a complex signaling cascade to regulate virulence gene expression in enterohemorrhagic ...

To study spatial interactions corresponding to the non-classical receptive field organization for human vision, we used a dual-masking paradigm to measure how target contrast discrimination can be affected by the relative location of the flankers. The observers' task was to detect a 4 cycle/deg vertical Gabor superimposed on a matching Gabor pedestal in the presence of vertical Gabor flankers. ...

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and may result in potentially fatal hemolytic uremia syndrome in humans. EHEC colonize the intestinal mucosa and promote the formation of actin-rich pedestals via translocated type III effectors. Two EHEC type III secreted effectors, Tir and EspFu/TccP, are key players for pedestal formation. We discovered that an EHEC...

Signals from rods can alter chromatic discrimination. Here, chromatic discrimination ellipses were determined in the presence of rod incremental and decremental pedestals at mesopic light levels. The data were represented in a relative cone Troland space, normalized by discrimination thresholds measured along the cardinal axes without a rod pedestal. In the quadrant of cone space where L-cone r...