We show that in certain compactifications of M-theory on eight-manifolds to threedimensional Minkowski space-time the four-form field strength can have a non-vanishing expectation value, while an N = 2 supersymmetry is preserved. For these compactifications a warp factor for the metric has to be taken into account. This warp factor is non-trivial in three space-time dimensions due to Chern-Simo...

Many fields are interested in how videogames can generate emotion but most have a very limited conception of what emotional response includes. This paper presents a comprehensive model of emotional response to the singleplayer game based on two roles players occupy during gameplay and four different types of emotion. The emotion types are based on different ways players can interact with a vide...

peripheral neuroepitbelioma (pn) is a rare highly malignant tumor, classified in the group of small round cell tumors. we report eight cases of pn, based on histologic appearance and immunohistochemical staining for neuron-specific enolase (nse). electron microscopy was also performed in three cases. the tumors exhibited rapid local growth, leading to limb amputation in five cases. histological...

the optimum shape of balance weights is determined, using two different criteria. according to one, one of the balance weights should have minimum size. while the other requires that the mass moment of inertia about the axis of rotation should be minimum. in the second case, the calculus of variation is used to determine the optimum shape. graphs are presented to enable designers to find the di...

One of the most pressing challenges is how to take advantage of the unprecedented opportunities that exist today for progress in biomedical research. Recent advances in the understanding of basic cellular and molecular processes provide the opportunity for us not only to unravel the mysteries of normal physiology but also to identify specific defects that contribute to the pathophysiology of va...

The editorship of Circulation Research changes as of this issue. We wish Dr. Marbán and his new Associate Editors well and take this opportunity to highlight some of the key features of our editorship, which began in 1991 at Boston and ends in 1999 at Pittsburgh. It is important to keep in mind that in 1991 the application of molecular biology to cardiovascular research was well underway. Our g...

A well-designed performance measurement system is vital for ensuring that organisations deliver cost-effective, high-quality services that meet the needs of service users. Without feedback on all important aspects and a system for ensuring that the organisation acts on that information, managers are struggling in the dark to improve services. However, performance measurement is not easy, partic...

Let C be a smooth complete algebraic curve of genus g and C2g−2 ⊂ Pg−1 the canonical model. It is generally difficult to describe its equations for higher genus. We restrict ourselves to the case of genus 8. If C has no g7, then C14 ⊂ P7 is a transversal linear section [G(2, 6) ⊂ P14] ∩H1 ∩ · · · ∩H7 of the 8-dimensional Grassmannian ([Muk2]). This is the case 〈8 〉 of the flowchart below. In th...

The field of phylodynamics, which attempts to enhance our understanding of infectious disease dynamics using pathogen phylogenies, has made great strides in the past decade. Basic epidemiological and evolutionary models are now well characterized with inferential frameworks in place. However, significant challenges remain in extending phylodynamic inference to more complex systems. These challe...