Antecedent hypoglycemia can blunt counterregulatory responses to subsequent hypoglycemia. It is uncertain, however, if prior hypoglycemia can blunt counterregulatory responses to other physiologic stresses. The aim of this study, therefore, was to determine whether antecedent hypoglycemia attenuates subsequent neuroendocrine and metabolic responses to exercise. Sixteen lean, healthy adults (eig...

Elevation of plasma nonesterified fatty acid (NEFA) levels has been shown in various studies to induce peripheral tissue insulin resistance and impair the suppression of endogenous glucose production (EGP). These studies have been conducted predominantly in men. We compared the effects of elevated plasma NEFA levels on basal and insulin-stimulated glucose metabolism in 8 normal women (age 42 +/...

School has to qualify students to use mathematical knowledge and competences in a flexible way in different situations. For that they have to understand fundamental concepts and techniques of mathematics. They have to be able to use standard-procedures to solve problems in well-known situations as well as to use flexible different strategies to solve non-routine problems. Learning the basics li...

The bispecific monoclonal antibody (bsAb) BIS-1 combines a monoclonal-antibody(mAb)-defined specificity for the CD3 complex, as present on all T lymphocytes, with a mAb-defined specificity for the pancarcinoma/epithelium associated glycoprotein EGP-2. In vitro studies indicate that BIS-1 can direct T lymphocytes to kill EGP-2-positive tumour target cells. T cell pre-activation is necessary for ...

Residual feed intake (RFI), defined as the differences between observed and expected feed intake based on growth and backfat, has been used to select for improved feed efficiency in beef cattle, poultry, and now swine. However, little is known about the main biological factors that contribute to the variation in RFI in swine. The objectives of the experiments in this thesis were to compare the ...

BACKGROUND All previous studies that investigated the association between abdominal fat distribution and insulin resistance evaluated subcutaneous and visceral fat area and/or volume, but these values were not related to the body type of each subject. In the present study we have examined the association between abdominal fat distribution and peripheral (muscle)/hepatic sensitivity to insulin u...

OBJECTIVE Olanzapine (OLZ) is an atypical antipsychotic whose clinical efficacy is hampered by side effects including weight gain and diabetes. Recent evidence shows that OLZ alters insulin sensitivity independent of changes in body weight and composition. The present study addresses whether OLZ-induced insulin resistance is driven by its central actions. RESEARCH DESIGN AND METHODS Sprague-D...

OBJECTIVE To investigate the pharmacodynamic profile and duration of action for five subcutaneous doses of insulin detemir (0.1, 0.2, 0.4, 0.8, and 1.6 units/kg; 1 unit = 24 nmol) and one subcutaneous dose of NPH insulin (0.3 IU/kg; 1 IU = 6 nmol). RESEARCH DESIGN AND METHODS This single-center, randomized, double-blind, six-period, crossover study was carried out as a 24-h isoglycemic clamp ...

This paper puts forward the implementation feasibility as the fourth dimension parameter to balance 3 d parameters of training quality, cost and time aiming at the selection of rural in-service teacher training scheme. It designs the implementation feasibility and the hierarchical structure model of implementation feasibility index. It puts forward implementation feasibility probability of ever...