1Department of Molecular and Biomedical Pharmacology, Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536, USA 2Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 N. Broadway, Baltimore, MD 21205, USA 3Eleanor Roosevelt Institute and the Department of Biological Sciences, University of Denver, 2101 E. Wesley Avenue, Den...

down's syndrome (ds) is the most common chromosomal abnormality in human. subjects with ds are known to be peridisposed to develop leukemia. the molecular basis of the association between ds and leukemia is unknown. the unscheduled dna synthesis (uds) test measure the ability of dna-repair in mammalian cells after excision of a stretch of dna containing the region of damage induced by chem...

We report an extremely rare case of Turner syndrome mosaicism in a 30-year-old woman. At least 100 metaphases were observed and analyzed through GTG banding with over 550 band resolutions observed. G-banded chromosome analysis revealed a mosaic female karyotype involving 3 different cell lines. One cell line (90% of the analyzed metaphases) presented monosomy X, while 6% of the cells showed tri...

Understanding attitudes of the public toward people with Down syndrome is important because negative attitudes might create barriers to social integration, which can affect their success and quality of life. We used data from two 2008 U.S. surveys (HealthStyles(c) survey of adults 18 years or older and YouthStyles(c) survey of youth ages 9-18) that asked about attitudes toward people with Down ...

This paper examines language and number understanding in infants with Down syndrome and Williams syndrome and compares infant performance to that of adults. The crosssyndrome/ cross-domain studies demonstrate that the pattern of performance of infants with Down syndrome and Williams syndrome on two tasks assessing language and number cannot be derived from the pattern of profi ciencies and impa...

the purpose of the present study was to compare the mental health status of fathers and mothers (n = 191; 59.6% mothers) of children with educable mental disabilities on various dimensions including, depression, anxiety, physical complains, and social functioning. the sampling method was multilayer, cluster sampling from special education schools in mashhad. the general health questionnaire (gh...

KEY POINTS Adults with Down syndrome are predisposed to obstructive sleep apnoea/hypopnoea syndrome (OSAHS) due to overlap between the Down syndrome phenotype and OSAHS risk factors.The prevalence of OSAHS in adults with Down syndrome is estimated at 35-42%. This is up to ten-times higher than in the general adult population.Symptoms of OSAHS, including behavioural and emotional disturbances as...