OBJECTIVES To identify the common causes and contributory factors for high neonatal mortality in Pakistan and propose effective strategies to safeguard against it. METHODS This retrospective study was carried out in Neonatal Unit (NNU) of Rawalpindi General Hospital (RGH) from January 1995 to December 1996. Relevant prenatal information obtained from referral forms, admission files or attenda...

During a period of three years from 1996 to 1998, 124 infants (64 male and 60 female) with an age range of 1-6 months (mean age 1.5 months) with cholestasis were studied. Idiopathic neonatal hepatitis was the most common cause of cholestasis, accounting for 48 cases with a rate of 3'8.70% in a total of 124 patients, followed by galactosemia in 29 patients (23.38%) and extrahepatic biliary ...

BACKGROUND There is still no study evaluating the influence of gestational age (GA) per se on C reactive protein (CRP) and procalcitonin (PCT) reference intervals. We therefore investigated how length of gestation, age (hours), and prenatal and perinatal variables might influence the levels of CRP and PCT. We also determined 95% age-specific reference intervals for CRP and PCT in healthy preter...

RATIONALE In response to injury, the rodent heart is capable of virtually full regeneration via cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished as early as 1 week postnatal and remains lost in adulthood. The mechanisms that dictate postinjury cardiomyocyte proliferation early in life remain unclear. OBJECTIVE To delineate the role of miR-34a, a re...

Removal of the superior colliculus (SC) in neonatal Wistar rats results in a rapid loss of retinal ganglion cells (RGCs). There is an early twofold increase in RGC death 4-8 hr postlesion (PL) followed by a later 10-11-fold increase in pyknosis about 24 hr PL. We have now used neurotrophic factors (BDNF, NT-4/5, NT-3, NGF, LIF), glutamate receptor antagonists (MK-801, DNQX, CNQX), an antioxidan...

To study the clinical Evaluation of obstetrics forceps in patients with prolonged 2nd stage of labour and evaluate its associated neonatal and maternal outcomes. It was an observational cohort study over a period of one year from July 2013 to June 2014, conducted at JLN Medical college/Hospital, Ajmer. During this study period, a total of 19082 women were delivered, of which 512 underwent force...

background: the admission test (at) has been carried out for many years, but there are still debates about the prognostic value of the test. therefore, we aimed to examine the value of the at in predicting the adverse outcome in neonates. methods: in this cross-sectional study, 425 pregnant women with normal vaginal delivery were studied between2009 and 2014at vali-e-asr hospital. based on the ...

BACKGROUND Growing technological capacity and parent and professional advocacy highlight the need to understand public expectations of newborn population screening. METHODS We administered a bilingual (French, English) Internet survey to a demographically proportional sample of Canadians in 2013 to assess preferences for the types of diseases to be screened for in newborns by using a discrete...