نتایج جستجو برای: e6 papilloma virus
تعداد نتایج: 404233 فیلتر نتایج به سال:
A replication-defective recombinant retrovirus containing the human papilloma virus E6/E7 genes (LXSN-16 E6E7) was used to immortalize stromal cells from human marrow. The E6/E7 gene products interfere with the function of tumor-suppressor proteins p53 and Rb, respectively, thereby preventing cell cycle arrest without causing significant transformation. Twenty-seven immortalized clones designat...
Etiologic studies of acute febrile disease were conducted in sites across South America, including Cusco and Iquitos, Peru. Patients' clinical signs and symptoms were recorded, and acute- and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) ...
Results Of 764 PCR positive samples there were sequenced 77 and 10 DNAs on genes L1 (296 bp) and E6/E7 (620 bp) HPV-16 regions, respectively. The phylogenetic analysis of gene L1 region established that generally all samples from Belarus clustered round reference-sequences from South East Asia and Europe, only 15 and 9 samples formed independent groups with each other. p-distances between the B...
سابقه و هدف: سرطان سرویکس دومین سرطان شایع در میان زنان، در سراسر جهان بوده و همچنین رتبه دوم مرگ و میر در میان سرطان ها، به خصوص در سنین بین 65-25 سال، دارد. برای ایجاد سرطان سرویکس یک سری تغیرات سلولی لازم است تا یک دیسپلازی به کارسینومای مهاجم تبدیل شود و از آن جایی که HPV(Human Papilloma virus ) ژنیتال دارای انکوژن های (E6 وE9) لازم برای ایجاد این تغییرات در اپیتلیوم سرویکس می باشد، امروزه ...
A mouse model incorporating the epitheliotropic nature of human papillomavirus (HPV) infections has been used to study an immune response to HPV type 16 (HPV-16) E6 protein in vivo. Using a transplantation technique, a novel immortal keratinocyte cell line expressing the E6 protein has been grafted onto syngeneic mice to re-form a differentiated epithelium overlying a granulation tissue bed. By...
A phenotypic high-throughput cell culture screen was performed to identify compounds that prevented proliferation of the human Papilloma virus type 16 (HPV-16) transformed cell line Ca Ski. A series of quinoxaline compounds exemplified by Compound 1 was identified. Testing against a panel of cell lines demonstrated that Compound 1 selectively inhibited replication of all HPV-16, HPV-18, and HPV...
Human papillomavirus (HPV) replication occurs in terminally differentiating epithelium, and requires the activation of cellular DNA replication proteins. Unscheduled DNA replication can result in the induction of apoptosis, and the viral E6 protein induces the degradation of p53 to prevent this. It has recently been shown that HPV-18 E6 can also stimulate the degradation of Bak, a pro-apoptotic...
Human papilloma virus (HPV) was isolated from red plaques of a patient (N. F.) with epidermodysplasia verruciformis. Electron microscopic examination showed characteristic particles of papilloma virus as icosahedrons about 45 nm in diameter. DNA was extracted from these particles, and closed-circular DNA (Form I) was purified by centrifugation in CsCl containing ethidium bromide. The molecular ...
Human papilloma virus (HPV) infection is a very common infection of skin and mucosa of children and adults (1- 6).Anogenital warts are a common type of HPV infection in sexually active adults, however it is seen in any age. The importance of presence of genital warts is different between adults and children in respect to differential diagnosis, associations, complications and also treatment opt...
The cell cycle regulatory genes p16/CDKN2 and RB are frequently deleted in prostate cancers. In this study, we examined the role of alterations in p16 and pRb during growth, senescence, and immortalization in vitro of human prostate epithelial cells (HPECs). HPECs are established from normal prostate tissues and cultured on collagen-coated dishes. Our results show that p16 is reproducibly eleva...
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