Non-small cell lung cancer (NSCLC) is the leading form of and adenocarcinoma (LUAD) its most common histotype. Tumor size, part TNM-staging, important for prognosis treatment guidance. Response to Tyrosine Kinase Inhibitors, e.g. Gefitinib, altered with certain epidermal growth factor receptor (EGFR+) gene mutations making time-to-progression (TTP) predictions difficult. We therefore developed ...

Using comprehensive high-frequency state and local sales tax data, we show that shopping behavior responds strongly to changes in rates. Even though taxes are not observed posted prices have a wide range of rates exemptions, consumers adjust many dimensions. They stock up on storable goods before rise increase online cross-border both the short long run. The difference between short- long-run s...

AIM Fructose consumption is associated with altered hepatic function and metabolic compromise and not surprisingly has become a focus for perinatal studies. We have previously shown that maternal fructose intake results in sex specific changes in fetal, placental and neonatal outcomes. In this follow-up study we investigated effects on maternal, fetal and neonatal hepatic fatty acid metabolism ...

OBJECTIVES/HYPOTHESIS To evaluate and describe the cartilaginous and muscular development of the rat larynx. STUDY DESIGN Histologic evaluation. METHODS The larynges of Sprague Dawley rats of embryonic day (E) 13, 15, 17, 19, 21, postnatal day 0, 14, and adult of 250 gm were collected. Four larynges of each age were harvested, cut into 15-μm serial sections, stained with hematoxylin and eos...

Neurogenesis in the rat neostriatum was examined with [(3)H]thymidine autoradiography. For the animals in the prenatal groups, the initial [(3)H]thymidine exposures were separated by 24 h; they were the offspring of pregnant females given two injections on consecutive embryonic (E) days (E13-E14, E14-E15, … E21-E22). For the animals in the postnatal (P) groups, the initial [(3)H]thymidine expos...

Congenital diaphragmatic hernia (CDH) has a high mortality rate mainly due to lung hypoplasia and persistent pulmonary hypertension of the newborn (PPHN). Simvastatin has been shown to prevent the development of pulmonary hypertension (PH) in experimental models of PH. We, therefore, hypothesized that antenatal simvastatin would attenuate PPHN in nitrofen-induced CDH in rats. The efficacy of an...

Three-dimensional reconstructions of the normal rat embryonic (E) neocortex on days E15, E17, E19, and E21, using Skandha (software designed by J. Prothero, University of Washington, Seattle), show that the neocortical ventricular zone shrinks rapidly in the medial direction during cortical morphogenesis. [3H]thymidine autoradiography indicates that the shrinkage of the ventricular zone occurs ...

Ultrafast and temporally precise action potentials (APs) are biophysical specializations of auditory brainstem neurons; properties necessary for encoding sound localization and communication cues. Fundamental to these specializations are voltage dependent potassium (KV) and sodium (NaV) ion channels. Here, we characterized the functional development of these ion channels and quantified how they...

The paper focuses on regional trade agreements and economic co-operation and develops a new appropriate approach to study their impact on growth and trade. The approach is based on an endogenous trade-growth theory and novelly specified in an economic integration (expenditure) framework which is the conceptual foundation of regional trade agreements. Importantly, it also appropriately takes int...