Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus. An 8-year-old child presented a pigmented lesion in the buttock since birth, but with progre...

Background: Nevus spilus can produce considerable disfigurement. There is no specific and successful treatment for this nevus. Objective: The purpose of this study was to evaluate the efficacy of CO2 laser in the treatment of nevus spilus. Patients and Methods: This quasi-experimental clinical trial was performed on 47 patients with spilus nevus in Al-Zahra Hospital in Isfahan. The diagnosis of...

Nomenclature This pigmentary disorder is known by different names in various literatures. They are listed out here to avoid confusion. 1. Acquired bilateral nevus of Ota-like macules (ABNOM) 3, 10-13 2. Nevus fusco-caeruleus zygomaticus 4 3. Hori's nevus 10, 12,14 4. Acquired circumscribed dermal facial melanocytosis 5. In Taiwan, it is known as 褐藍色顴痣, which is translated from ''nevus fusco-cae...

OBJECTIVE To analyze dermoscopically identified streaks by direct correlation with features visualized on reflectance confocal microscopy (RCM). DESIGN We evaluated by RCM melanocytic lesions showing peripheral streaks on dermoscopy. A digital camera connected to the RCM computer enabled direct analysis of the streaks. The lesions were excised and histopathologically analyzed. SETTING Derma...

“Abtropfung” vs “Hochsteigerung”. Arch Dermatol. 2007;143(2):284. 2. Hofmann-Wellenhof R, Blum A, Wolf IH, et al. Dermoscopic classification of atypical melanocytic nevi (Clark nevi). Arch Dermatol. 2001;137(12):15751580. 3. Rieger E, Kofler R, Borkenstein M, Schwingshandl J, Soyer HP, Kerl H. Melanotic macules following Blaschko’s lines in McCune-Albright syndrome. Br J Dermatol. 1994;130(2):2...

Somatic mutations of BRAF have been identified in both melanoma tumors and benign nevi. Germ line mutations in BRAF have not been identified as causal in families predisposed to melanoma. However, a recent study suggested that a BRAF haplotype was associated with risk of sporadic melanoma in men. Polymorphisms or other variants in the BRAF gene may therefore act as candidate low-penetrance gene...

BUMC PROCEEDINGS 2001;14:377 A34-year-old male internist working at a large teaching hospital died of metastatic melanoma 3 years after a silent primary tumor was discovered by his wife. The patient’s wife, a pediatric resident, noted the lesion on his back after attending a lecture on melanoma and premelanoma. The patient had been seen annually by his primary care physician, and during these e...

BACKGROUND We have identified cases of skin cancer with discordances between clinical, dermoscopic, and histopathologic findings that were likely due to sampling errors in the pathology laboratory. This has prompted us to explore the use of ex vivo dermoscopy as an ancillary method of gross pathology, which may serve to guide tissue sectioning. Noncontact polarized dermoscopy was applied to pig...

Using an avidin:biotin immunoperoxidase system with monoclonal antibodies to lymphocyte subsets, we have investigated the host response to malignant melanoma and melanocytic nevi in frozen sections. Eight primary melanomas, eight metastases, three dysplastic nevi, and two dermal nevi were studied with antibodies T11, T4, T8, and B1. Sections were read in a semiquantitative manner by two observe...

The following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated ne...