This short paper presents an abstract, tunable model of genomic structural change with in the cell lifecycle and explores its use with simulated evolution. A well-known Boolean model of genetic regulatory networks is extended to include changes in node connectivity based upon the current cell state, e.g., via transposable elements. The underlying behaviour of the resulting dynamical networks is...

We appreciate the generous support of the National Science Foundation (IOC Award #0323176), the Stanford Technology Ventures Program, and the MIT Sloan School of Management. We also thank multiple individuals for their helpful comments, including Phil Anderson, Steve Barley, Diane Burton, Tim Carroll, Rebecca Henderson, Pankaj Ghemawat, Clark Gilbert, Riitta Katila, Bruce Kogut, Dan Levinthal, ...

Certain areas of scientific research flourish while others lose advocates and attention. We are interested in whether structural patterns within citation networks correspond to the growth or decline of the research areas to which those networks belong. We focus on three topic areas within optical physics as a set of cases; those areas have developed along different trajectories: one continues t...

The move towards a semantic web will produce an increasing number of presentations whose creation is based upon semantic queries. Intelligent presentation generation engines have already begun to appear, as have models and platforms for adaptive presentations. However, in many cases these models are constrained by the lack of expressiveness in current generation presentation and animation langu...

MetaObject Protocols (M.O.P) recently deened for C++ Chi93a] do not t the needs of evolution in DataBases Management Systems (D.B.M.S.). In this paper, we present DyReCT, an extension of C++ that allows instances migration, reeection and run-time classes modiications. Thanks to a metalevel, these new functionalities are transparent for the user. DyReCT should fulll our future needs for data per...