Despite almost a decade since the introduction of Dynamic Causal Modelling (DCM), there remains some confusion within the wider neuroimaging, neuroscience and clinical communities as to what DCM studies are probing, and what all the jargon means. We provide ten simple rules, and a theoretical example to gently introduce the reader to the rationale behind DCM analyses, and how one should conside...

We present molecular dynamics simulations on the structural relaxation of a simple bead-spring model for polymer blends. The introduction of a different monomer size induces a large time scale separation for the dynamics of the two components. Simulation results for a large set of observables probing density correlations, Rouse modes, and orientations of bond and chain end-to-end vectors, are a...

We present the implementation of dynamic electrostatic force microscopy in liquid media. This implementation enables the quantitative imaging of local dielectric properties of materials in electrolyte solutions with nanoscale spatial resolution. Local imaging capabilities are obtained by probing the frequency-dependent and ionic concentration-dependent electrostatic forces at high frequency (>1...

Ever since their introduction two decades ago, single-molecule (SM) fluorescence methods have matured and branched out to address numerous biological questions, which were inaccessible via ensemble measurements. Among the current arsenal, SM fluorescence techniques have capabilities of probing the dynamic interactions of nucleic acids and proteins via Förster (fluorescence) resonance energy tra...

Visual cortex contains a set of field maps in which nearby scene points are represented in the responses of nearby neurons. We tested a recent hypothesis that the visual field map in primary visual cortex (V1) is dynamic, changing in response to stimulus motion direction. The original experimental report replicates, but further experimental and analytical investigations do not support, the inte...

This paper studies the reduction of the conservativeness of robust nonlinear model predictive control (NMPC) via the reduction of the uncertainty range using guaranteed parameter estimation. Optimal dynamic experiment design is formulated in the framework of robust NMPC in order to obtain probing inputs that maximize the information content of the feedback and simultaneously to guarantee the sa...

Crowding occurs when nearby flankers impede the identification of a peripheral stimulus. Here, we studied whether crowded features containing inaccessible emotional information can nevertheless affect preference judgments. We relied on gaze-contingent crowding, a novel method allowing for constant perceptual unawareness through eye-tracking control, and we found that crowded facial expressions ...

Live cell optical sensing employs label-free optical biosensors to non-invasively measure stimulus-induced dynamic mass redistribution (DMR) in live cells within the sensing volume of the biosensor. The resultant DMR signal is an integrated cellular response, and reflects cell signaling mediated through the cellular target(s) with which the stimulus intervenes. This article describes the uses o...

Important biological mechanisms, such as signal transduction and gene expression, are mediated by numerous interacting multifunctional molecules, whose expression and activation are tightly regulated in space and time in response to stimuli. In order to describe the network of functional inter-relationships that govern such mechanisms, we use simple algorithms to interpret multiple variable mea...