Non-ampullary duodenal adenoma with activation of Wnt/β-catenin signalling is common in familial adenomatous polyposis (FAP) patients, whereas sporadic non-ampullary adenoma is uncommon. The adenoma-carcinoma sequence similar to colon cancer is associated with duodenal tumors in FAP, but not always in sporadic tumors. We obtained 37 non-ampullary duodenal tumors, including 25 adenomas and 12 ad...

Real-time measurements for gut motility in conscious rats or mice combined with intracerebroventricular or intravenous injection of peptide agonists or antagonists allow us to understand the regulatory mechanism of gastrointestinal motility. Neuropeptide Y (NPY) in the arcuate nucleus in the hypothalamus stimulates the fasted motility in the duodenum, while urocortin in the paraventricular nucl...

The uptake capacity of the duodenum and jejunum was determined in vitro for glucose and methionine using 14C-inulin as an unabsorbed reference substance in posthatch chicks. Fatty acid uptake in situ was also determined in the duodenum. Methionine uptake capacity increased in both duodenum and jejunum between hatch and 7 d and was constant between 7 and 14 d. Calculation of apparent Michaelis c...

PURPOSE As a foundation for a dose escalation trial, we sought to characterize duodenal and non-duodenal small bowel organ motion between fractions of pancreatic radiation therapy. PATIENTS AND METHODS Nine patients (4 women, 5 men) undergoing radiation therapy were enrolled in this prospective study. The patients had up to four weekly CT scans performed during their course of radiation thera...

The addition of ginger and milk powder rejected in the feed can improve work organs digestion. This research was conducted with aim knowing effect adding ration at different levels on internal organ profile broiler chickens. method used this study a completely randomized design factorial pattern 3 treatments (factor A) 4 B) using 2 replications for each replication or experimental unit containi...

The mechanisms of type 2 diabetes remission after bariatric surgery is still not fully elucidated. In the present study, we tried to simulate the Roux-en-Y gastric bypass with a canonical or longer biliary limb by infusing a liquid formula diet into different intestinal sections. Nutrients (Nutrison Energy) were infused into mid- or proximal jejunum and duodenum during three successive days in ...

The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in cAMP-stimulated HCO3- secretion across the murine duodenum was investigated. Serosal-to-mucosal flux of HCO3- (Js-->m, in mu eq.cm-2.h-1) and short-circuit current (Isc; in mu eq.cm-2.h-1) were measured by the pH stat method in duodenum from CFTR knockout [CFTR(-)] and normal [CFTR(+)] mice. Under control conditions, ...

fer with a diagnosis of gastrointestinal bleeding from a duodenal diverticulum. An apparent bleeding diverticulum was visualized on repeat endoscopy at the junction of the second and third part of the duodenum (l" Figure 1). Computed tomography scan revealed a large (15 ” 10 cm) heterogeneous centrally hemor− rhagic mass in the right anterior parare− nal space, abutting both the pancreas and th...

The distinctive motor activity of duodenal bulb is incompletely understood. Thus, in six conscious sheep the myoelectric activity of pyloric antrum, duodenal bulb and distal duodenum were continuously recorded in order to assess the myoelectric patterns of duodenal bulb and the relationships to adjacent regions before and after feeding or cholinergic drug administration. It was found that in du...

Many growth factor receptors including the epidermal growth factor receptor function through tyrosine kinase activity. The aim of this study was to examine the constitutive level of tyrosine phosphorylation in the normal duodenum and in the hyperproliferative coeliac duodenum. A flow cytometric assay was devised using monoclonal antibody to phosphorylated (but not native) tyrosine residues to d...