RATIONALE AND OBJECTIVES Women who are invited for breast cancer screening should get enough information about the benefits and harms of screening to make an informed decision on participation. Personal invitations are an important source of information, because all invited women receive them. The objective of this study was to evaluate the information breast cancer screening units send to wome...

One of the issues of youth in Iranian society and Tehran city is drug use. Drug use is influenced by various factors (environmental and individual). In Bandura's cognitive-social learning theory, the process of integrating the individual and social factors on each other has been emphasized. Therefore, this research is shaped by this theory. The purpose of this article is to develop a model of d...

In last few years, the use of zebrafish (Danio rerio) in scientific research is growing very rapidly. Initially, it was a popular as a model of vertebrate development because zebrafish embryos are transparent and also develop rapidly. Presently, the research using zebrafish is expanding into other areas such as pharmacology, clinical research as a diseases model and interestingly in drug discov...

At the 2011 Yale Chemical Biology Symposium, Jason Gestwicki presented a novel yet intuitive approach to drug screening. This method, which he termed "gray box" screening, targets protein complexes that have been reconstituted in vitro. Therefore, the gray box screen can achieve greater phenotypic complexity than biochemical assays but avoids the need for target identification that follows cell...

Biosensors with animal and microbial cells immobilized close to the tip of a membrane electrode have been developed for chemical and drug testing. Our experimental results show that biosensors can be used for drug screening and to provide useful information about various cell-chemical interactions. A computer aided analysis (CAA) software package is being developed here using the biosensor for ...

Repurposing an existing drug for an alternative use is not only a cost effective method of development, but also a faster process due to the drug's previous clinical testing and established pharmokinetic profiles. A potentially rich resource for computational drug repositioning approaches is publically available high throughput screening data, available in databases such as PubChem Bioassay and...

This review discusses the reported studies investigating use of bioprinting to develop functional organ-on-chip systems from a manufacturing perspective. These model liver, kidney, heart, lung, gut, bone, vessel, and tumors demonstrate viability bioprinted for disease modeling drug screening. In addition, paper highlights challenges involved in using techniques system fabrications suggests futu...

Stimulants abuse is a global issue. Acute myocardial infarction, heart failure, and arrhythmia have all been linked to stimulants misuse its synthetic variants but are rather uncommon. Herein, we present case of young patient presented with atrial fibrillation that did not respond digoxin therapy. A suspicion drug toxicity was later confirmed bedside urine screening. Following administration be...