نتایج جستجو برای: drug toxicity
تعداد نتایج: 637719 فیلتر نتایج به سال:
Male infertility accounts for about 50% of infertility cases [1]. Anatomic, genetic, endocrinological, environmental, behavioral and nutritional imbalances are critical causes of male infertility [2-5]. Therapeutic drugs can also adversely affect male fertility by injuring testicular cells or instigate hormonal changes that lead to decreased semen quality (Figure 1) thereby compromising the pro...
The use of medicines in children is an area of increasing after this syndrome was noted, pharmacokinetic studies showed that newborn infants had impaired metabolism interest [1]. Many medicines are being used outside the terms of their product licence [2] thereby increasing of chloramphenicol and that a reduction of the dosage from 100 mg kg−1 daily to 50 mg kg−1 daily prevented the risk of dru...
It’s a big problem driven by a big success. Doxorubicin (Adriamycin; Pfi zer) and other anthracyclines effectively treat leukemias, lymphomas, and several types of solid tumors, including breast cancer. The success of these chemotherapies is one driver of the dramatic improvements in survival rates for childhood cancers since the 1970s. Sadly, the drugs have been linked to subsequent heart fail...
An entire cycle of preclinical studies 4-[(3-ethoxy-3-oxopropanoyl)amino]benzoic acid (etmaben) exhibiting cardiotropic action was carried out. Its potential mechanism and pharmacological effects, general toxic effects in acute chronic experiments, specific types toxicity (allergenicity, immunotoxicity, reproductive toxicity, mutagenicity), pharmacokinetics were studied. The drug found to have ...
Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that regulate cellular levels of ROS, as their reactive nature may otherwise cause damage to key cellular components including DNA, protein, and lipid. When the cellular antioxidant capacity is exceeded, o...
Treatment-related toxicity in acute lymphoblastic leukemia (ALL) can not only be life threatening but may also affect relapse risk. In 240 patients, we determined whether toxicities were related to 16 polymorphisms in genes linked to the pharmacodynamics of ALL chemotherapy, adjusting for age, race (self-reported or via ancestry-informative markers), sex, and disease risk group (lower- vs highe...
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