PURPOSE The purpose of this work was to preparation of vancomycin (VCM) biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W) multiple emulsion method. METHODS The vancomycin-loaded nanoparticles were created using double-emulsion solvent evaporation method. Using Eudragit RS100 as a coating material. The prepared nanoparticles were identifyed...

Planned in-situ radiosensitization may improve the therapeutic ratio of image guided I prostate brachytherapy. Spacers used in permanent implants may be manufactured from a radiosensitizer-releasing polymer to deliver protracted localized sensitization of the prostate. Such devices will have a limited drug-loading capacity, and the drug release schedule that optimizes outcome, under such a cons...

The purpose of this research was to formulate and systematically evaluate in vitro performances of chitosan microspheres containing Mitomycin-C. Chitosan microspheres containing Mitomycin-C were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-link...

In present study mucoadhesive buccal tablet of simvastatin was prepared. Solubility of Simvastatin was enhanced by complexing Simvastatin with β-CD in 1:2 molar concentrations. Six different formulations of tablets of Simvastatin containing the polymers in various combinations were prepared by direct compression method and characterized for swelling studies, % matrix erosion, surface pH, mucoad...

Antibody-drug conjugates (ADC) are an emerging drug class that uses antibodies to improve cytotoxic drug targeting for cancer treatment. ADCs in current clinical trials achieve a compromise between potency and physicochemical/pharmacokinetic properties by conjugating potent cytotoxins directly to an antibody at a 4:1 or less stoichiometric ratio. Herein, we report a novel, polyacetal polymer-ba...

The purpose of this research was to formulate and systematically evaluate in vitro performances of chitosan microspheres containing Mitomycin-C. Chitosan microspheres containing Mitomycin-C were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-link...

An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

the objective of the present study was to prepare controlled release formulation of moxifloxacin hydrochloride ocular nanoparticles. the nanoparticles were prepared by solvent displacement method using eudragit rl 100 as a polymer. different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. the formulations were evaluated i...

We have investigated the stability, alpha-tubulin composition, and polarity orientation of microtubules (MTs) in the axons and dendrites of cultured sympathetic neurons. MT stability was evaluated in terms of sensitivity to nocodazole, a potent anti-MT drug. Nocodazole sensitivity was assayed by quantifying the loss of MT polymer as a function of time in 2 micrograms/ml of the drug. MTs in the ...