In this study, we synthesized dendrimer-functionalized laponite (LAP) nanodisks for loading and delivery of anticancer drug doxorubicin (DOX). Firstly, LAP was modified with silane coupling agents and succinic anhydride to render abundant carboxyl groups on the surface of LAP. Then, poly(amidoamine) (PAMAM) dendrimer of generation 2 (G2) were conjugated to form LM-G2 nanodisks. Anticancer drug ...

A method for repeatable loading of propranolol hydrochloride as a model drug onto the ion exchanger Amberlite TM IRP69 was developed and different parameters for the loading process were evaluated due to their impact of the extent of loading. It was found that the extent of loading in equilibrium is widely independent of the experimental method used. However, a magnetic stirrer comminutes the i...

objective(s): the purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (ba) enhancement of potent sulfonamide- type loop diuretic- furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an adjunct in acute pulmonary edema. the comparatively poor and inconstant b...

By attaching multiple copies of the influenza M2 ion channel inhibitors amantadine (1) and rimantadine (2) to polymeric chains, we endeavored to recover their potency in inhibiting drug-resistant influenza viruses. Depending on loading densities, as well as the nature of the drug, the polymer, and the spacer arm, polymer-conjugated drugs were up to 30-fold more potent inhibitors of drug-resista...

An integrated γ-cyclodextrin-gated mesoporous silica delivery system via dual dynamic covalent bonds was constructed with dual drug loading for simultaneous and cascade release in targeted combination drug therapy.

In recent years, there is a lot of interest in synthesis of nanostructures as carriers for drug delivery.These structures are considered as a highly effective drug delivery system due to controlling drugrelease, protecting the pharmaceutical molecule, and environmentally friendly. In this study, thesynthesis of chitosan nanoparticles was carried out by chemical method. The nan...

A simple and straightforward method of self-assembling grafted copolymers was developed to fabricate cross-linked polymer vesicles, which could conjugate anticancer drug cis-platinum and possess the capability of a high drug loading content, and a steady release rate.

The encapsulation of anticancer drugs in a liposome structure protects the drug during circulation and increases drug accumulation in the cancer tissue and antitumor activity while decreasing drug toxicity. This paper presents a new method of active drug loading based on a vitamin C pH/ion gradient. Formulations were characterized in terms of the following parameters: optimal external pH, time ...

in this work we synthesized nano hydroxyapatite (hap)  by sol-gel method, then we functionalized hydroxyapatite nanoparticle by use of  3-aminopropyl trimethoxysilane (aptms) , to improve the loading and control release of sulfasalazine drug bonded to aptms. the drug release patterns from sulfasalazine loaded hap nanoparticles at ph value 8 for 6h, sulfasalazine loaded functionalized hap nanopa...