The majority of natural history studies of human immunodeficiency virus (HIV) infection have immune and viral parameters in men. Data demonstrating that women have lower HIV-1 RNA levels than men at the same CD4 cell counts have raised the question of immunologic differences in HIV-seropositive women. This study describes levels and changes in phenotypic markers of immune maturity, function, an...

Contemporary thinking about tardive dyskinesia is undergoing a quiet revolution. In the fourth decade following the introduction of neuroleptic medications for the treatment of schizophrenia, tardive dyskinesia research has moved from debates over its very existence to careful, scholarly sub-typing of clinical variants. Investigators are also beginning to elucidate the epidemiology and natural ...

Retrospective studies of administrative databases have led to highly variable estimates of the incidence and natural history of drug-induced liver injury (DILI) and the agents implicated. In contrast, prospective multicenter registry studies allow for more accurate phenotyping of individual patients with DILI, as well as for collection of biological samples for mechanistic studies. In addition ...

Multiple myeloma is an incurable malignant disorder of mature B-cells that predominantly affects the elderly. The immunomodulatory drug (IMiD) thalidomide and its newer analogs demonstrate increased antitumor activity, and have had a positive impact on the natural history of multiple myeloma. Recent advances in the clinical application of these agents and in our understanding of their mechanism...

OBJECTIVES To observe the nature and frequency of adverse reactions caused by accidental peanut exposure in young children with clinical peanut hypersensitivity and to determine the value of serum peanut-specific IgE levels during follow-up. STUDY DESIGN Eighty-three children with clinical peanut hypersensitivity diagnosed before their fourth birthdays were contacted yearly to track adverse p...

Human immunodeficiency virus (HIV) infection is epidemic among intravenous drug users (IVDU), particularly in the northeastern United States. IVDU are playing a critical role in the spread of HIV by infecting their heterosexual partners and children, as well as their needle-sharing partners. The epidemiology of HIV infection among IVDU is reviewed here, including a compilation of seroprevalence...

Background In natural history of allergy, in some patients sensitized to aeroallergens, appear allergy to novel allergens, and in some cases this are food allergens. Subcutaneous immunotherapy (SIT) is the method of treatment patient with pollen allergy, and one of the aim of this treatment is protection against development novel allergy, but sometimes in clinical practice we observed hypersens...