HIV infection causes various acute and chronic cutaneous disorders such as rash, seborrheic dermatitis-like eruption, alopecia, herpes simplex and Kaposi’s sarcoma, some of which are associated with immunosuppression. HIV infection down-regulates various types of functional properties of CD4+ helper and regulatory T cells, leading to the devastating immunosuppression in the majority of infected...

A 90-year-old woman was seen with a generalized bullous eruption. She did not remember suŒering from similar lesions previously. She had hypertension treated for more than one year with hydrochlorothiazide and valsartan (Co-diovanâ ). Six weeks before the start of cutaneous lesions, nimodipine (Nimotopâ ) and ginko biloba (Tanakeneâ ) had been added to her therapy. In October 2000 she received ...

BACKGROUND Drug-induced hypersensitivity syndrome/drug rash with eosinophilia with systemic symptoms (DIHS/DRESS) is a severe drug eruption accompanied by multiorgan disorders. Several unique aspects of DIHS/DRESS, including herpesvirus reactivation, liver dysfunction and hypogammaglobulinaemia, have similarities to graft-versus-host disease (GVHD). AIM In this study, we focused on the dynami...

A 68-year-old man presented with a generalized papular eruption with oedema of the face and the hands, fever and pustulosis in intertriginous areas which had begun 1 day after starting treatment with EuvanolA nasal spray (plant extracts and benzalkonium chloride) and DolirhumA (paracetamol and pseudoephedrine). He has been hospitalized 8 years before for a similar eruption associated with hyper...

No matter how typical a cutaneous eruption may be in a patient with the acquired immunodeficiency syndrome, early histologic evaluation is necessary if a delay in diagnosis and treatment is to be avoided. We report the case of a 33-year-old man with acquired immunodeficiency syndrome who was clinically misdiagnosed as having a drug-induced eruption. Three weeks later he died with disseminated h...

BACKGROUND Linear IgA bullous dermatosis is an autoimmune blistering disease characterized clinically by the presence of small tense blisters and immunologically by the presence of IgA at the dermal-epidermal junction. Idiopathic, systemic disease-related, and drug-related versions of this disorder have been described, with the latter most commonly associated with vancomycin. OBSERVATIONS We ...

In March 2012, a Salvadoran-American boy aged 7 years living in Maryland developed three slightly painful, well-demarcated, flat, gray-brown patches on his torso. A dermatologist in Washington, DC, suspected a fixed drug eruption (an erythema multiforme-like adverse drug reaction that occurs in the same location each time the person uses a particular medication). The child had recently taken a ...

Fixed drug eruption is a cutaneous reaction which occurs by repetitive exposure to the offending drugs like antimicrobials, anticonvulsants and NSAIDS. Here we are presenting a case of 65 year old male of fixed drug eruptions due to administration of injections diclofenac sodium. Diclofenac is a commonly used anti inflammatory drug for relieving pain.