AIM Diabetic retinopathy (DR) is the most common preventable cause of blindness where early detection and treatment can be sight-saving. Search for biomarkers of the disease has been relentless. We aimed to determine whether lipoproteins apolipoproteins A1 and B1 (Apo-A1 and Apo-B1) have stronger associations with DR in contrast to conventionally measured low-density lipoprotein (LDL) and high-...

negative. There was no known maternal history of herpes simplex infection, candidal vaginitis, intrauterine device (IUD) usage, cervical cerclage, or amniocentesis. The mother tested positive for group B Streptococcus and received antibiotics before delivery. The mother had artifi cial rupture of membranes 2 hours before delivery, and there were no signs of chorioamnionitis. On examination, the...

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I ntroduction: In recent years a number of emerging new therapies have become available for the treatment of severe asthma among which bronchial ther-moplasty is the only nonpharmacologic intervention that has been approved by the United States Food and Drug Administration in 2010. 1 Although bronchial thermoplasty has great promise for the patient with severe asthma and is now within the thera...

We appreciate the opportunity to reply to Dr. Kotze's and Dr. Yamamoto's letter1 about our paper “Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn's disease: an open-label pilot study”, recently accepted for publication in JCC.2 We agree with the first comment concerning the hypothesis that the use of anti-TNF (tumor necrosis factor)-α before surgery...

Opioids contribute to 70% of the negative health impact associated with drug use disorders. A new opioid withdrawal protocol using over-the-counter medications loperamide and P-glycoprotein inhibitor (omeprazole) was described by Dr Al Garhy previously. In this article successful protocol, evidenced Clinical Opiate Withdrawal Scale, is discussed in a case series.

PURPOSE To quantify changes in retinal microvasculature in diabetic retinopathy (DR) by using spectral-domain optical coherence tomography angiography (SD-OCTA). METHODS Retrospective, cross-sectional, observational study of healthy and diabetic adult subjects with and without DR. Retinal microvascular changes were assessed by using SD-OCTA images and an intensity-based optical microangiograp...

I read Dr Kern’s article on the technique of subareolar blue dye injection with great interest. I was also interested in Dr Kern’s reply to the letter by Dr Ahmad Shatila. I was particularly intrigued by the comment made by Dr Kern that the sentinel lymphatic channels provide access to the same sentinel lymph nodes that receive lymph flow from peritumoral injections, and most importantly, that ...

OBJECTIVES The main objective was to indicate sufficient general anaesthesia (GA) inhibition for negative experience rejection in GA. PATIENTS AND METHODS We investigated the group of patients (n = 17, mean age 63.59 years, 9 male--65.78 years, 8 female - 61.13 years) during GA in open thorax surgery and analyzed EEG signal by power spectrum (pEEG) delta (DR), and gamma rhythms (GR). EEG was ...

Despite studies concerning toxic reactions related to amalgam components in the literature, few studies have been devoted to evaluate local noxious effects of amalgam tattoos (AT) on biological tissues. In addition, little is known about activation of inflammatory cells by mucosa-implanted amalgam debris. Tissue reaction to AT depends on the particle size. Human leukocyte antigen DR (HLA-DR) is...