OBJECTIVE To measure test accuracy of non-invasive prenatal testing (NIPT) for Down, Edwards and Patau syndromes using cell-free fetal DNA and identify factors affecting accuracy. DESIGN Systematic review and meta-analysis of published studies. DATA SOURCES PubMed, Ovid Medline, Ovid Embase and the Cochrane Library published from 1997 to 9 February 2015, followed by weekly autoalerts until ...

The anesthesiological approach to rare diseases (RD) is particularly challenging for providers. The high number of pathologies and the scarcity of clinical reports impedes to arrange a pool of dedicated anaesthesiologists. When facing RD, the risk linked to unaware malpractice is often due to lack of experience, mostly of urgent/emergent procedures [1]. It is probably impossible to know all rel...

In the structural design of light wood structures in recent years, people have paid more and attention to estimating lateral deformation buildings. order better estimate balsa shear wall without hold-downs, this paper carried out loading test monotonic nail joint. A formula for load-deformation nodes suitable engineering entities is proposed. method calculating walls hold-downs provided. The ba...

In this paper, we propose a PID parameter tuning of particle swarm optimization for multiobjective optimization characteristics of two regional power system PID controller design. By defining a comprehensive consideration of system output overshoot, rise time and the fitness function term steadystate error indicators, such as the ITAE, and in accordance with the performance requirements of the ...

INTRODUCTION The maternal experience of having a young infant is often viewed through a negative lens focused on psychological distress due, in part, to a historical focus on identifying threats to prenatal, perinatal and postpartum well-being of women and infants. This report examines maternal appraisal of both positive and negative experiences during and after pregnancy and introduces a new s...

ergy? That tantalizing question reflects a dream that some have hoped to realize by exploiting the energy-storage capabilities of nuclear isomers. But the hope hinges on facets of nuclear behavior that remain unknown despite decades of study. Electromagnetic transitions and b decay, the basic mechanisms that largely determine isomer halflives, are well understood. In many cases, however, it is ...

We have implemented an incremental lexical acquisition mechanism that learns the meanings of previously unknown words from the context in which they appear, as a part of the process of parsing and semantically interpreting sentences. Implement at ion of this algorithm brought to light a fundamental difference between learning verbs and learning nouns. Specifically, because verbs typically play ...