BACKGROUND With the aging of the global population, an increasing number of elderly are diagnosed with advanced non-small cell lung cancer. Although systematic chemotherapy has been one of the primary treatments for advanced non-small cell lung cancer worldwide, the elderly cannot always tolerate standard platinum-based doublet chemotherapy, thus resulting in treatment failure. To reduce toxici...

Iron is an important constituent of kornerupine, (M,Mg,Fe)(Al,Mg,Fe)9(Si,Al,B)5O21(OH,F). We obtained Mössbauer spectra at 300 K on twelve samples with SFe 5 0.30–1.30 atoms per formula unit (apfu) and Fe31/SFe 5 0–0.31; several samples were also run at 77 and 430 K. Models allowing unequivocal refinement of the spectra and determination of site occupancies were developed only when single-cryst...

Differences in doublet analysis have the potential to alter DNA cell-cycle measurements. The techniques for doublet determination are often used interchangeably without regard for the complexity in cell shapes and sizes of biological specimens. G(0/1) doublets were identified and quantitated using fluorescence height versus area and fluorescence width versus area pulse measurements, by enumerat...

Experimental observations on cyclic splitting and bending by a flagellar doublet pair are modeled using forces obtained from a model for dynein mechanochemistry, based on ideas introduced by Andrew Huxley and Terrill Hill and extended previously for modeling flagellar movements. The new feature is elastic attachment of dynein to the A doublet, which allows movement perpendicular to the A double...

BACKGROUND Xenograft and mathematical models have shown that the antitumor activity of capecitabine can be increased by modifying the schedule from 14 days on, 7 off (14/7) to 7/7. MATERIALS AND METHODS Capecitabine at two-thirds maximum tolerated dose (MTD) administered using 14/7 (267 mg/kg) and 7/7 (467 mg/kg) schedules, alone and in doublet and triplet combinations with irinotecan (40 mg/...

The stiffness (flexural rigidity) of live sperm flagella, Triton-demembranated flagella (axonemes), trypsin-digested axonemes, and doublet microtubules of the axonemes in echinoderms was determined from the relationship between their deformation when a stream of medium was applied and the viscous resistance of the medium acting on the flagellum. The stiffness of the flagellum beating in seawate...

The most general SU(2) × U(1)Y -symmetric quartic potential with two Higgs doublets, subject to an only softly broken discrete symmetry (φ1, φ2) → (−φ1, φ2), is considered. At tree-level, analytic bounds on the parameters are derived that ensure a stable vacuum, breaking SU(2)× U(1)Y down to U(1)em. email: [email protected] In the minimal standard model, spontaneous symmetry breaking of t...