BACKGROUND The purpose of this study was to investigate lecithin-chitosan nanoparticles as a topical delivery system for quercetin. METHODS Tocopheryl propylene glycol succinate was chosen to be the surfactant for the nanosystem. The mean particle size of the nanoparticles was 95.3 nm, and the entrapment efficiency and drug loading for quercetin were 48.5% and 2.45%, respectively. Topical del...

Silica nanoparticles are versatile platforms with many intrinsic features, such as low toxicity. Proper design and derivatization yields particularly stable colloids, even in physiological conditions, and provides them with multiple functions. A suitable choice of dyes and synthetic strategy may, in particular, yield a very bright nanosystem. Silica nanoparticles thus offer unique potential in ...

Voltage-controlled resistive switching in various gap systems on SiO2 substrates is reported. The nanoscale-sized gaps are made by several means using different materials including metals, semiconductors, and amorphous carbon. The switching site is further reduced in size by using multiwalled carbon nanotubes and single-walled carbon nanotubes. The switching in all the gap systems shares the sa...

We have proposed a bottom-up nanosystem-fabrication method, which consists of production of nano-blocks and radicals (adhesives) in reactive plasmas, transport of nano-blocks towards a substrate, their arrangement on the substrate using pulse RF discharges with the amplitude modulation (AM) of discharge voltage. In this study, we report transport of nano-blocks by AM discharges using an electro...

A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of do...

A photon-to-thermal conversion nanosystem has been developed to rapidly elevate temperatures in poorly thermally conducting media using irradiation of gold nanorods. We first hypothesized that nanoparticles, especially gold nanorods, are capable of generating enough heat to lyse bacteria by heating sample solutions via laser irradiation. To test this, we synthesized Au nanorods (aspect ratio 3-...

Harvesting energy from multiple sources available in our personal and daily environments is highly desirable, not only for powering personal electronics, but also for future implantable sensor-transmitter devices for biomedical and healthcare applications. Here we present a hybrid energy scavenging device for potential in vivo applications. The hybrid device consists of a piezoelectric poly(vin...