Previous studies suggested that y87 Gln in hemoglobin (Hb) F is an important site for promoting inhibition of Hb S (cy#: polymerization by H b F. We engineered and isolated the double mutant ) using a yeast expression system and characterized polymerization properties of this modified tetramer in an effort to clarify the role of Gln at position 87 in inhibiting H b S polymerization. Electrop...

In a cooperative effort between research groups from Dortmund (Germany, coat of arms on the left) and Cuernavaca (Morelos, México, right), novel molecular cages were synthesized characterized by state-of-the-art analytical methods DFT calculations. Among these compounds, spacer-bridged tetraorganodistannoxane in centre showing double-ladder structure exhibits record spacing opposite tin centres...

The sudden approximation (SA) for scattering of atoms from surfaces is generalized to allow for double collision events and scattering from time-dependent quantum liquid surfaces. The resulting new schemes retain the simplicity of the original SA, while requiring little extra computational effort. The results suggest that inert atom (and in particular He) scattering can be used profitably to st...

Patients with thalassemia major, intermedia or double eterozygous with sickle cell disease are exposed to a major risk of developing hepatocellular carcinoma (HCC). Transfusion-transmitted viral infections and long standing iron overload represent principal carcinogenic risk factors. Every effort should be made to prevent tumor development, whose prognosis is usually dismal, or at least to make...

The MAJORANA collaboration[1] aims to detect neutrino-less double beta decay (0νββ) in Ge, using an array of germanium p-type point contact detectors. An important factor in this effort is the minimization of backgrounds from any hardware which is needed to operate the detectors. In order to best understand and minimize this background, one must analyze the gamma spectrum from these pieces of h...

The paper describes a radial network procedure of numerical optimization backed by full-wave numerical analysis. To reduce computational effort, 3D FDTD data are added to the database as long as they are needed to achieve appropriate accuracy. The method involves optimization of the regularization parameter and radial function’s radius. Performance of the procedure is illustrated by optimizing ...

Counterinsurgency, which is the effort to mitigate support for an opposing organization, is one such domain that has been studied recently and past work has modeled the problem as an influence blocking maximization that features an influencer and a mitigator. While past work has introduced scalable heuristic techniques for generating effective strategies using a double oracle algorithm, it has ...

We present new factors of seventeen Mersenne numbers, obtained using a variant of the special number field sieve where sieving on the algebraic side is shared among the numbers. It reduced the overall factoring effort by more than 50%. As far as we know this is the first practical application of Coppersmith’s “factorization factory” idea. Most factorizations used a new double-product approach t...

The Guaranteed Frame Rate service category is currently under discussion for incorporation into the specification documents of the ATM-Forum. The concept of the GFR service is to provide a minimum service guarantee to classical best-effort services, taking into account the frame-based nature of todays data-traffic. In this paper we present a discrete-time analysis of the GFR service and discuss...

Product customization has been used for many years, and with this concept, product families can be designed that are better matched to the needs of customers through the use of market segmentation and modular architecture. This study is composed of two phases: the first phase establishes the modular architecture, and taking a bicycle as the case study, applies the Interpretive Structural Model ...