A unified proteochemometric (PCM) model for the prediction of the ability of drug-like chemicals to inhibit five major drug metabolizing CYP isoforms (i.e. CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) was created and made publicly available under the Bioclipse Decision Support open source system at www.cyp450model.org. In regards to the proteochemometric modeling we represented the chemical comp...

The calculation of vertical electronic transition energies of molecular systems in solution with accurate quantum mechanical methods requires the use of approximate and yet reliable models to describe the effect of the solvent on the electronic structure of the solute. The polarizable continuum model (PCM) of solvation represents a computationally efficient way to describe this effect, especial...

Techniques from model-driven software development are useful to analyse the performance of a software architecture during early development stages. Design models of software models can be transformed into analytical or simulation models, which enable analyzing the response times, throughput, and resource utilization of a system before starting the implementation. This chapter provides an overvi...

A study to evaluate the reproductive performance of Abergelle goat was carried out at Sekota District of Amhara National Regional State. On-farm flocks from two peasant associations were monitored for two years to collect data. Data collected included identification number of doe and kid, birth / kidding date, kid birth weight, sex of kid, post partum doe weight, litter size, parity of doe. Dat...

[1] The radiative effects from increased concentrations of well-mixed greenhouse gases (WMGHGs) represent the most significant and best understood anthropogenic forcing of the climate system. The most comprehensive tools for simulating past and future climates influenced by WMGHGs are fully coupled atmosphere-ocean general circulation models (AOGCMs). Because of the importance of WMGHGs as forc...

this study aims to evaluate effects of two downscaling methods; change-factor and statistical downscaling on therunoff of the azam-harat river located at yazd province (with an arid climate) of iran, under the a2 emission scenariofor the period of 2010-2039. for this purpose, cgcm3-ar4 model; a rainfall-runoff conceptual model, ihacres; twodownscaling models, change factor and lars-wg were appl...