The objective of this research was to analyze the anti-diabetic properties of the bioactive compounds extracted from P. urinaria using molecular docking servers. Two extracts were prepared using distilled water and chloroform as solvents by optimized maceration procedure. Determination of phytochemical constituents of these extracts was then carried out by using standard set of protocols. GC-MS...

This paper studies multiple cross-dockings where the loads are transferred from origins (suppliers) to destinations (customers) through cross-docking facilities. Products are no longer stored in intermediate depots and incoming shipments are consolidated based on customer demands and immediately delivered to them to their destinations. In this paper, each cross-docking has a covering radius tha...

The rapidly growing number of theoretically predicted protein structures requires robust methods that can utilize low-quality receptor structures as targets for ligand docking. Typically, docking accuracy falls off dramatically when apo or modeled receptors are used in docking experiments. Low-resolution ligand docking techniques have been developed to deal with structural inaccuracies in predi...

Background: Multidrug resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression/overactivation of ABC transporters, especially P-glycoprotein (P-gp), in the development of chemotherapy has long been demonstrated. Salinispora is a marine actinomycete genus known for the production of novel bioactive metabolites. Methods: In this...

Olfactory receptors (ORs) belong to the class A G-Protein Coupled Receptor superfamily of proteins. Unlike G-Protein Coupled Receptors, ORs exhibit a combinatorial response to odors/ligands. ORs display an affinity towards a range of odor molecules rather than binding to a specific set of ligands and conversely a single odorant molecule may bind to a number of olfactory receptors with varying a...

The aim of the study was to investigate the effect of tail-docking on the LH pulse frequency in femaleTuj lambs. Twelve female lambs were assigned into two equal groups. A rubber ring was applied to the baseof the tail for shedding off. Blood samples were collected for 8 h in the 4th and 8th months of age todetermine pulsatile secretion of LH. Starting from the age of 6 months, blood samples we...

objective(s):in recent years, the chemistry of tetrazolo[5',1':2,3][1,3,4]thiadiazepino [7,6-b]quinolines have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity. as the inhibitor of aldose reductase, the aforementioned compounds may have implication in preventing complications of diabetes. ...

UNLABELLED Sliding Box Docking is a program that manages simulations of ligand docking at different defined positions of a three-dimensional DNA structure. The procedure is similar to inverse docking, which is a method that performs docking simulations of a single ligand in the active sites of different targets. Sliding Box Docking manages docking simulations of one ligand into a box that slide...

Vacuole inheritance in yeast involves the formation of tubular and vesicular "segregation structures" which migrate into the bud and fuse there to establish the daughter cell vacuole. Vacuole fusion has been reconstituted in vitro and may be used as a model for an NSF-dependent reaction of priming, docking, and fusion. We have developed biochemical and microscopic assays for the docking step of...