Abstract DNA nanostructures constructed under the guidance of nanotechnology have developed rapidly for last two decades, standing at forefront in biomedical field. Among them, tetrahedron nanostructure (DTN) has emerged as one most representative nanostructures. DTN was easily formed by one-step annealing four single-stranded DNA. Due to its unique advantages such simple and stable structural ...

The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein (CRISPR/Cas) system has been exploited as an efficient gene editing tool with precise site specificity and high efficiency; the delivery of CRISPR/Cas is critical for efficacy therapeutics remains challenging. DNA nanomaterials are widely utilized promising carriers agents because their excellent molecular...

DNA nanotechnology offers a versatile toolbox for precise spatial and temporal manipulation of matter on the nanoscale. However, rendering DNA-based systems responsive to light has remained challenging. Herein, we describe remote native (non-photoresponsive) chiral plasmonic molecules (CPMs) using light. Our strategy is based use photoresponsive medium comprising merocyanine-based photoacid. Up...

Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes display...

Among the key goals of structural DNA nanotechnology are to build highly ordered structures self-assembled from individual DNA motifs in 1D, 2D, and finally 3D. All three of these goals have been achieved with a variety of motifs. Here, we report the design and characterization of 1D nanotubes and 2D arrays assembled from three novel DNA motifs, the 6-helix bundle (6HB), the 6-helix bundle flan...